Herceptin (trazumab 440) freezed by mistake

[Karthik08]

I accidentally freezed Herceptin drug(trazumab 440mg) for one day. I haven't opened it yet, I kept it in the freezer of my home refrigerator directly when I recieved it from the pharmacy. Can I use it now? Will it be effective? Or is it best to buy a new one?

[IronWill123]

The storage temperature of Trastuzumab is 2 to 8 Deg C. So if it got frozen it will be ineffective. It is advisable to purchase new one. I have read somewhere, it's efficacy goes down by 10% for every 1 Deg C temperature above or below its storage temperature.

[Karthik08 in reply to IronWill123]

Thanks a lot for the reply. In the box it says "Do not freeze the reconstituted solution." I haven't even opened the box. And hence I was asured that the medicine will be good to use and need not be replaced. Do you still think it is adviced to purchase a new one? Please help me out with this!

[IronWill123 in reply to Karthik08]

Yes, I think so. The storage temperature of the lyophilised powder is also in the range of 2-8Deg C.

[IronWill123 in reply to Karthik08]

Also, I hope you are getting Intas Pharma - Eleftha

[MsLockYourPosts TeamBCI in reply to Karthik08]

Talk to your pharmacist or doctor. They have probably dealt with this question before.