Hi, My Mother, age 55 has been detected with Duct Carcinoma on 10th Oct'19, had undergone surgery - Lt Side Quadractomy with axillary lymph nodes. The biopsy report states - Infiltrating Duct Carcinoma grade III. Size of tumor 1*0.6cm, Left AXLN-0.8,*0.6 cm, 4*2.8 cm necrotic lymph nodes in left axillary tail. With 15 out of 31 axillary lymph nodes showing metastasis. FISH HER report yet to come. ER-positive (30% tumor nuclei shows moderate intensity.) PR - negative.
PET CT Scan shows - Few tiny lung nodes on the left upper lobe and along bilateral fissures seen with no significant uptake.
Reactive tiny-subcm left level II and IV neck nodes.
Doctors have prescribed Granisetron 1mg, Dexamethasone 12 mg, Cyclophosphamide 900mg, Epirubric 140 mg, Dexamethasone 4mg
As this is the first breast cancer case in our family. I wanted to understand a few questions:
1) What does ER, PR and HER mean - and what does it mean with positive and negative
2) With regard to the nodes in the neck and lungs (PER Report)- doctors have said that the chemo will take care of these as well. However, after the chemo how do we ensure that the nodes are not malignant?
3) Also, I want to understand what does "Infiltrating Duct Carcinoma stage III mean. What are the chances of recurrence? How should we take care of it?