Hi there. After 5 years on Tamoxifen, and being 55 now post-menopausal, I switched to Anastrozole a few months ago together with Alendronic Acid (as I found out I also had osteoporosis). I was initially really pleased not have that unpleasant 'simmering' feeling I endured throughout the 5 years on Tamoxifen. However - I don't know whether it was a combination of the two (or not) but after a couple of months I started to develop terrible aches in my legs, (worse at night) present in both but stronger on the left side, especially in thigh bone. Went to GP who did blood tests/xrays on legs which came back clear. She suggested stopping the biphosphonates which I did - no difference. She then suggested stopping the Anastrozole which I have done for around 2 weeks now - no difference. I have an appt with the onc at the end of this week but wondered whether anyone else has experienced this and what the outcome was?