OH/OH 125 problem

[Ruth-S]

Hello,

I wonder if anyone's doctor has talked about a OH/OH 125 issue as a possible issue in osteoporosis? I don't understand what this explanation means - is it about Vit D levels or something else?

I would love to hear your thoughts. Thank you.

ods.od.nih.gov/factsheets/V...

[Jubux]

I suspect they are talking about a possible vitamin D issue. What is not widely understood is that it is someone’s 1,25 dihydroxyvitamin D level that must be within the right limits for bone health (and many other things), rather than the 25 hydroxyvitamin D. In most people, the cheap-to-measure precursor 25 (OH) D gives a reliable indication of the extremely-difficult-and-expensive-to-measure 1,25 D, so that is what is done. Unfortunately for some of us, that is not always true. For example, someone with sarcoidosis or other granulatomous diseases may have a very low 25D even if their 1,25D is too high because their 25D is converted to 1,25D at a faster rate than normal. Too much 1,25D is as bad as too little for the bones. See if you can get both tested, and believe the 1,25D result. Note that if your doctor says no to testing for 1,25D they could test for parathyroid hormone (PTH) instead because PTH will be low if 1,25D is high. If there is a chance of you having one of the medical conditions that might mess with vitamin D sensitivity, you certainly should be properly assessed before taking supplements.

grassrootshealth.net/blog/g...

[Ruth-S in reply to Jubux]

Thank you so much. This is very helpful.

[Nannie-C]

ask Dr to fully check your parathyroid glands (NOT same s thyroid but sadly so often overlooked) by taking samples of calcium, vit d and parathyroid all from same blood draw to assess their relationships at that time. This is what can lead to diagnosis of Hyperparathyroidism, a common cause of bone loss. Treatable with small op allowing bones and body start to heal.

[Ruth-S in reply to Nannie-C]

Thank you! Much appreciated!