I recently saw a locum specialist (my usual pulmo was away). I told him that I felt that Symbicort was of limited effect after taking it for some 6-7 years of varying strengths - currently 400/12 (I also take Spiriva). He suggested I try Seretide 250 and gave me a sample. I tied it today as my morning "starter". At first it didn't seem that different....but wait more was in store......my shower was a bit more breathless than usual as was the towelling down. Breakfast was much more breathless. Suffice to say after an hour of panting and feeling pretty piXXed off, I took a suck of Symbicort and whilst not a sigificant great I felt significantly better. I guess the moral is - "Whilst it is OK to try new medications from time to time - they are not always beneficial". Stay well!