exciting research into lung regrowth !

A UT Arlington bioengineering researcher has teamed with a UT Southwestern colleague to develop a nanoparticle drug delivery system that will help stimulate lung growth and function after partial lung removal or destructive lung disease.

Kytai Nguyen, an associate professor of bioengineering, is working on the drug-delivery portion of the project, which is funded through a $3.4 million National Institutes of Health grant through 2016. Nguyen’s work will be underwritten by $440,000 of the larger grant.

“We will introduce drugs through inhaled nanoparticles that will stimulate lung growth and remodeling following partial lung removal,” said Nguyen, who joined UT Arlington’s College of Engineering in 2005 and holds a joint appointment with UT Southwestern Medical Center of Dallas. “We will synthesize biocompatible, biodegradable polymers that will encapsulate, or load, and release the drugs where needed.”

The polymer used to house the drugs will degrade with time, allowing the drugs to be released within the lung. Various polymers can be used to control this drug-release time. Magnetic or fluorescent labels may be incorporated into the nanoparticles as tracers initially, but omitted in final therapeutic formulations.

Connie Hsia, a professor of Internal Medicine at UT Southwestern will direct the overall project. She said that once the drugs are delivered via nanoparticles, the research team would be able to measure therapeutic response using non-invasive imaging, physiological testing, and detailed structural analysis.

“This research is important because currently there is no definitive cure for most destructive lung diseases except transplantation,” Hsia said. “We have shown that partial lung removal may trigger regrowth of the remaining lung to compensate for the loss. Using nanoparticle as a vehicle for delivery of therapeutic compounds, we hope to amplify the lung’s innate potential for regrowth.”

Nguyen and Hsia hope their work will lead to better quality of life for people who have had a part of their lungs removed by surgery or destroyed by disease.

Nguyen has studied how physical and biological factors influence the proliferation of vascular smooth muscle cells, a condition that can lead to heart disease. She also has conducted research using focused laser beams called optical tweezers in nanoparticle-cell manipulation with Samarendara Mohanty, a UT Arlington associate physics professor.

Nguyen’s work is representative of the research under way at The University of Texas at Arlington, a comprehensive undergraduate and graduate institution of nearly 33,000 students in the heart of North Texas. Visit uta.edu to learn more.

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  • That is very interesting Julie,I must go onto the sight, to learn more.Thanks xxx

  • PS<meant site lol!!

  • I have just read the same research - how exciting! TAD x

  • Sounds very interesting

  • Is anyone interested in taking part in research based in Nottingham? I signed up with the Nottingham Respiratory Research Unit at the City Hospital and have attended one session (next one in early February).

    Each session lasts a couple of hours and includes questions and some light exercise for them to assess you.

    No medication changes, no extra medications, you can stop at any point and attend sessions as often or infrequent as you want - I get the distinct impression that they simply don't have enough volunteers.

    They will pay transport costs (if you need it) and ply you with cups of tea ;-)

    I understand that it will not benefit me ... the research is longer term than that, but hell, why not - for me it's only a few miles.

    You can read more at nottingham.ac.uk/scs/divisi...

  • good morning

    very interesting thank you for poit it out i am waiting to talk to my daughter who is switzerland working on chemical incorperation in other fields it looks the way to go, or one of them and is possible biologicaly it is just funds at this time well done the USA

    have a good day keep the bugs at bay

    richard

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