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Reducing organ transplant side-effects

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A new research project aims to use personalised anti-rejection medication to reduce the health risks that organ transplant patients experience following surgery.

Third-year PhD student Sarah Dart, from The University of Western Australia’s Medical School, said her research aimed to optimise immunosuppressant drug use, by analysing how the immune system responds to an organ following transplantation.

“Developing personalised treatment strategies is important, because patients have unique immune responses to donated organs, regardless of whether they are a genetically identical match to the organ donor,” Ms Dart said.

“After organ transplant surgery, patients undergo ongoing medical assessment and take immunosuppressant drugs for their lifetime. This leaves patients vulnerable to contracting infectious diseases, such as COVID, and at greater risk of developing cancer.

“These severe side effects can be mitigated by minimising the number of immunosuppressant drugs each patient needs to take or optimising those drugs to better target specific immune cells.”

The research involves looking at immune cells from transplanted organs under the microscope to analyse how each cell responds to immunosuppressant drugs.

“Using fluorescent proteins called antibodies, which bind to different immune cells, we can identify and track what happens to the cells within the transplanted organ,” Ms Dart said.

uwa.edu.au/news/Article/202...

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2greys

youtube.com/watch?v=e57kMnm...

HungryHufflepuff profile image
HungryHufflepuff

This sounds really hopeful and promising.

Caspiana profile image
Caspiana

Can't happen soon enough. ,👏

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