‘Universal Covid vaccine’ could be de... - Lung Conditions C...

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‘Universal Covid vaccine’ could be developed within a year, Second-generation jab may work against all variants of coronavirus.

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Scancell Holdings plc, (AIM:SCLP), the developer of novel immunotherapies is pleased to announce that they have selected theirCOVID-19 vaccine candidate, SN14,for further development and clinical trials. SN14targets both the SARS-CoV-2 nucleocapsid (N) protein and the key receptor-binding domain (RBD) of the spike (S)protein, and is based on a modification of Scancell’s Immuno Body®DNA vaccine technology.

Fifteen vaccine candidates containing different S and N components combined with a variety of targeting technologies were evaluated for the bestT cell and antibody responses. SN14 reproducibly elicited high-titre anti-S virus neutralising antibodies (VNAbs) together with high avidity T cells against both the S and N proteins. SN14 also incorporates Scancell’s Avidi Mab™technology to further enhance this immune response demonstrating the broad potential of this platform technology to generate improved vaccines for both infectious diseases and cancer.

SN14 is asecond generation vaccine which offers several potential advantages over currently approved and late-stage COVID-19vaccines:

•Not only does SN14target the S protein to induce VNAbs that prevent the COVID-19 virus from entering cells but also induces strong T cell responses to both the S and N proteins to destroy virally-infected cells and prevent further viral replication.

•As the N protein is well-conserved between coronaviruses, the SN14 vaccine has the potential to be effective against any variant or new strain of coronavirus in addition to the current COVID-19 strain.

•Use of the Avidi Mab™ technology increases the potency of the T cell response which, in turn,should lead to long-term protection and immunological memory.

•DNA vaccines are exceptionally stable, do not require ultra-low temperature storage and are manufactured using relatively simple processes.

scancell.co.uk/Data/Sites/1...

news.sky.com/story/covid-19...

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Izb1 profile image
Izb1

This sounds very promising x

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Sharp5Flat13

Thanks for posting 2greys.

Spectabilis profile image
Spectabilis

Thank you for posting this. I didn't come across your post until yesterday, a day after getting the 1st dose of Moderna.....I am 41, diagnosed 3 years ago with ET JAK2+ and only medication is 81mg of aspirin daily. I had an excruciating migraine, chills, fatigue, and 100F low grade fever. I spoke to a friend who is a nurse and she said her co-workers were saying the effects are due to dehydration. I am sure I was dehydrated because we traveled 4 hours to get the vaccine and I didn't want to have to stop anywhere. This is a rough time for us all. I have been doing so much research. I wish I knew more about biology and the immune system. What I have found about the S protein and the PROS1 gene mutation has me concerned. Have any of us been tested for the PROS1 gene mutation? I have not. It is directly related to the blood clotting function of the S protein. What if our bodies do not respond correctly to the mRNA and it messes up yet another function of our blood systems? So many questions. These vaccines are all an experiment. Probably the largest in our History. I haven't read the links yet that you added but I will be doing so, thanks again.

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2greys in reply to Spectabilis

I regularly post research and study links, if you are interested click on my screen name to find a list of all my posts.

We will see how things pan out but I'm not upsetting myself by getting my hopes up.