Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production.

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Despite the widespread application of vaccination programs and antiviral drug treatments, influenza A virus (IAV) infections are responsible for significant morbidity and mortality. Influenza infections can also result in sporadic and often devastating pandemics; the 1918 pandemic led to the death of 50 million people. Severe bacterial infections can occur in the aftermath of IAV infection and contribute significantly to the excess morbidity and mortality of influenza. Streptococcus pneumoniae was the most commonly detected bacteria in the 1918 and 2009 influenza pandemics. Murine models have shown that infection with IAV disrupts pulmonary barrier integrity and dampens innate antibacterial immunity, thus favoring local bacterial outgrowth and dissemination from the lungs.

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Is short chain fatty acid .... lippes