Rather than clutter the forum I have lumped them altogether within the same post, as they are all from the same source.
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Finding genetic cancer risks.
EMBL scientists describe how our genetic background influences cancer development. The Pan-Cancer project showed that there is a molecular clock in our cells.
news.embl.de/science/pan-ca...
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Chromothripsis in human cancer
Newly discovered mutational phenomenon chromothripsis is prevalent across more cancers than previously thought. Researchers at Harvard Medical School and EMBL-EBI have carried out the largest analysis across cancer types of the newly discovered mutational phenomenon chromothripsis. This study is the largest of its kind to date, containing whole-genome sequencing (WGS) data from over 2600 tumours spanning 38 different types of cancer.
news.embl.de/science/pan-ca...
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Scientists identify new genetic drivers of cancer
Analysis of whole cancer genomes gives key insights into the role of the non-coding genome in cancer. The discovery of genetic drivers of cancer can have critical implications for the diagnosis and treatment of cancer patients, yet genome analysis has focused primarily on only 1–2% of the whole genome – the part that contains the code for making proteins. What about the rest? Does it also play a role in driving the disease?
news.embl.de/science/pan-ca...
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Studying DNA rearrangement to understand cancer
Scientists use the Pan-Cancer dataset to study how structural variations in the genome can lead to cancer. Using the dataset from the Pan-Cancer project, a team including EMBL scientists has developed methods to group, classify, and describe structural variants – large rearrangements of the genome that are a key driver of cancer. Their findings could help to improve cancer diagnosis and therapy.
news.embl.de/science/pan-ca...
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Cancer mutations occur decades before diagnosis
A large-scale pan-cancer analysis of the evolutionary history of tumours reveals that cancer-causing mutations occur decades before diagnosis. Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI) and the Francis Crick Institute have analysed the whole genomes of over 2600 tumours from 38 different cancer types to determine the chronology of genomic changes during cancer development.
news.embl.de/science/pan-ca...
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Characterising RNA alterations in cancer
The largest and most comprehensive catalogue of cancer-specific RNA alterations reveals new insights into the cancer genome. Researchers at EMBL-EBI were among the leaders of a large international consortium that carried out a joint analysis of data from over 1000 donors of more than 25 cancer types, studying data on their whole genomes along with tumour transcriptome data, which indicates the genes that are active within a tumour. These data represent the largest comparative resource to date of cancer-specific RNA alterations matched with whole-genome sequencing data.
