Programmed ‘disarming’ of the neutrop... - British Lung Foun...

British Lung Foundation
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Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation.

2greys
2greys
4 Replies

The antimicrobial functions of neutrophils are facilitated by a defensive armamentarium of proteins stored in granules, and by the formation of neutrophil extracellular traps (NETs). However, the toxic nature of these structures poses a threat to highly vascularized tissues, such as the lungs. Here, we identified a cell-intrinsic program that modified the neutrophil proteome in the circulation and caused the progressive loss of granule content and reduction of the NET-forming capacity.

nature.com/articles/s41590-...

4 Replies
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Emily61

Right 2grey what does this mean neutrophils seems to be significant but I being stupid dont understand this finding. HELP! Will this help with copd.

2greys

Basically it has been discovered that Neutrophils have built in brake to their actions, now they need to find out how to manipulate that braking mechanism. Advances being made now albeit in little steps.

Emily61
Emily61
in reply to 2greys

Does this link into other research around G-CSF trying to get to grips now with what I am reading as I was revisiting G-CSF this evening as a research that appears to stem back from the 90s

2greys
2greys
in reply to Emily61

Very much so, very closely related. This still remains our best hope at arresting the progress.