Researchers discover how lungs cells respond to bacteria.

[2greys]

Previous research has shown that recovery from bacterial pneumonia hugely improves our defense against further infections by seeding the lungs with immune cells called lung resident memory T (TRM) cells, but how these cells actually protect the lungs against future bacterial infections has been unknown until now.

medicalxpress.com/news/2019...

[2greys]

This study ties in nicely in with another other post:

healthunlocked.com/blf/post...

That examines the G-CSF protein that stimulates specialised white blood cells called neutrophils and macrophages.In which lung tissue is slowly eaten away by chronic inflammation, the major culprits are those specialised white blood cells, neutrophils and macrophages.

This opens up the a question to me. Is this how getting Pneumonia or an infection actually causes the mechanism of the loss of lung function?

[Hidden in reply to 2greys]

Woukd it not be great to see an end in sight, with these findings. You are right both reports tie nicely together.

[Gladwyn in reply to Hidden]

It would be awesome Emily61 😀

[megshafer]

2 greys, this protein G-CSF...is relative to our white blood cells, which we know raise when we are ill, to fight infection. With us, having more white blood cells, or very many person's have a higher amount in their blood, with lung diseases. I have wondered and have thought about asking my physician....what about all those asthma medications that help with eosinophils, which are usually mentioned with macrophages and neutrophils......i have researched a good bit on this, and it makes me wonder....could these asthma shots stop or help stop or have a derivative that stops progression?

Just thinking..

Stay well, take care,🍁

Meg

[Hidden in reply to megshafer]

We could ask our consultants that question, I am going to ask mine. What a brilliant thought

[2greys in reply to megshafer]

I have Eosnophilia that is under control and stable with a high dose of inhaled corticosteroids, which now gives me a normal Eosinophil count. But still have a high Neutrophil count. Fortunately in my case the Pneumonia was caught and was treated relatively early, and hopefully limited any further damage. So whilst inhaled corticosteroids have helped lower the Eosinophil count, the Neutrophils obviously need a different approach to regulate.

It is this regulation that is going to be very difficult, too many Neutrophils will be bad for progressive damage, too little and that will be bad for fighting off infections. A simple self administered test may need to be developed, used in conjunction with a pharmacist who can give a blocker of the correct strength, on the day, thus avoiding the wait for doctor's appointment.