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Can Alzheimer’s Dementia Drugs Help With IPF ... Drug repurposing in idiopathic pulmonary fibrosis classes

12 Replies

Furthermore, our analysis concluded to drugs (Table 2) that provide strong connection with IPF since they have been discovered by at least two out of three drug repurposing tools, with a given inhibiting score less than −0.5 against IPF. We then used our scoring formula in order to re-rank all the potential IPF inhibiting drugs, that passed the aforementioned rules, based on their inhibiting, functional, structural and side effect scores for each stage of the disease. Of all the resulting drugs and through bibliographic research regarding their connection to IPF we propose certain drugs as potential competitors against IPF. Niclosamide has been highly ranked by CoDReS for every stage of IPF, it is in the same structural cluster with other potential IPF inhibitors and has also been mentioned to reverse fibrosis on the skin and lungs of mice that had Systemic Sclerosis with pulmonary fibrosis. Due to its safety profile, niclosamide can be considered for use in clinical trials against IPF. Anisomycin and Puromycin, natural compounds that both derive from the Genus of streptomyces, seem to have potential against IPF; Anisomycin is known to inhibit the induction of ER stress and Puromycin targets inflammatory cells. Etoposide and Irinotecan are used for cancer treatment and IPF is known to have similar mechanisms with various types of cancer.

Most of the specific mechanisms (Cell communication, ecm receptor interaction, focal adhesion, cytokine-cytokine receptor interaction and colorectal cancer) that were found in all experiments, are related to fibrotic or pulmonary diseases or to other pathways that are related to IPF. This is a means to test the validity of our methods but at the same time it points out more pathways, potentially involved in IPF. As seen in Table 10, most of the aforementioned pathways are targeted by repurposed drugs from our study. This strengthens our claims for new potential repurposed drug inhibitors for IPF.

In the case of microRNAs, hsa-miR-25-3p and hsa-miR-208a-5p can inhibit genes that the FDA approved drug nintedanib targets. This finding provides an insight for a new microRNA-based treatment approach.

Finally, the action of the remaining mechanisms and drugs that were found from our analysis, may be further investigated, since they have been derived from significantly relevant genes related to IPF stages.

nature.com/articles/s41598-...

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12 Replies
2greys profile image
2greys

Sorry that the answer to "Can Alzheimer’s Dementia Drugs Help With IPF " has to be NO. There are no updates to this and the paper is dated as being received by Nature.com on the17th of May 2017, that is over two years ago and the hypothesis for it was formulated a year before that even in 2016.

in reply to 2greys

Well your very wrong 2grays AND clearly not read paper or would see you are.

2greys profile image
2greys in reply to

Look at the bottom of the article. The dates are in black and white for all to see.

in reply to 2greys

That’s right AND advances have been made since then.

🔬 research science is not like pulling bunny 🐰 out of a hat 🎩

At least I ask what might seem daft questions ITs better than not in my opinion AND lucky enough my lung doctor finds merit in stuff talked about test requested.

2greys profile image
2greys in reply to

Again you are wrong, there are NO updates. Again at the bottom of the article is a link to search for updates and there are none!

in reply to 2greys

You believe what you want AND all belive what I want

SquirrelsHolt profile image
SquirrelsHolt

Afternoon JAS and I have to hold my hands up and declare that its going to take my small brain,a couple of readings,to really understand what the report concluded etc. Sorry I can't be of much assistance with positive comments ..... Well not til I've read it over again.

However, we can always rely on the JAS, giving us a run-down on what's what! Hope you and Dad are doing well, or as well as can be expected for your dear Dad. You know,I'm sure,that he is very proud of you,in the way you care for him and have his best interests at heart.

Have a good weekend!

in reply to SquirrelsHolt

Dad’s surviving not that is thankful most days GOOD job don’t do it for thanks BUT more tough love these days.

Anyway not much chance me getting hold dad’s Alzheimer’s Dementia drugs for my lung stuff as he’s not on any

Ant that usually the way

So feel bad for him AND me lol 😂

Ergendl profile image
Ergendl

At least some scientists are thinking about trialling drugs already in use, for other conditions besides their present licences. Where successful, the drugs would end up in the system a lot quicker than novel drugs.

in reply to Ergendl

Hi Ergendl defo agree and guess that’s what it’s all about .. getting stuff out there quicker if helps

I know when I asked my lung doctor about cf drugs for my issues he said could not be prescribed given current system

Lucky for me I have bronchiectasis so could access NOT sure if that’s lucky 🍀 tho

stamford1234 profile image
stamford1234

Dear Jeff, You have to look after yourself too

Bkin profile image
Bkin

I noticed Niclosamide is mention in this article for IPF patients also - linking to info recently posted:

healthunlocked.com/blf/post...

Sorry JAS is no longer with us.

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