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Annotation tool provides step toward understanding links between disease, mutant RNA

Researchers at Oregon State University have developed a computer program that represents a key step toward better understanding the connections between mutant genetic material and disease. Known as bpRNA, the software is a big-data annotation tool for secondary structures in ribonucleic acids.

“It’s capable of parsing RNA structures, including complex pseudoknot-containing RNAs, so you end up with an objective, precise, easily-interpretable description of all loops, stems and pseudoknots,” said corresponding author David Hendrix. “You also get the positions, sequence and flanking base pairs of each structural feature, which enables us to study RNA structure en masse at a large scale.”

today.oregonstate.edu/news/...

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