Been nebulising colomycin for 3 weeks at home after 10 days tazacin in hospital.. 3 more weeks to go. Is it usual to feel tired and weak whilst doing this? I have RA and recently had a depomedrone shot so l was expecting to feel much better than l do. My RA meds have been changed to sulfasazine and l no longer take methotrexate due to frequent chest infections. Due to colonisation by pseudomonas l feel that l have lost confidence in being able to deal with my problems on my own as l have done for many years before this. Does anyone have similar experiences.? I prefer to hear from people on this site rather than visit my GP. Thanks for taking time to read my post.