Severe asthma in humans and mouse model suggests a CXCL10 signature underlies corticosteroid-resistant Th1 bias

Asthma is a disease with significant prevalence and morbidity throughout the developed world, affecting nearly 5%–10% of populations. It is increasingly recognized that asthma is a disease with multiple phenotypes, each with its own unique molecular mechanisms, natural history, and response to therapy. Corticosteroids (CS) have remained the mainstay of therapy, but for many patients, these therapies are ineffective, and research of underlying mechanisms may give insight into the etiologies of CS resistance and identify future therapeutic targets.

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