Hi I'm a newbie and was diagnosed with COPD 6 years ago. I was hospitalised two years ago with an exacerbation and was told I also was retaining CO2. I am now on bi pap and constant oxygen. I have a question for anybody who has had trouble with thrush in the mouth from using inhalers. I am supposed to use ventolin, spiriva and secretive but after using for a few days develop really bad thrush making it impossible to eat or drink. The only relief is when I use Daktarin for it but I am on warfarin and this rais s my blood levels so high the Dr doesn't like me using it. I have tried the inhalers with a spacer, rinsing my mouth and brushing my teeth. Please.......if anybody has any advice?