Exenatide for Parkinson and Alzheimers. Another... - Ataxia UK

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Exenatide for Parkinson and Alzheimers. Another bit of hope for ataxia?

sunvox profile image
6 Replies

mlive.com/news/grand-rapids...

clinicaltrials.gov/ct2/show...

express.co.uk/life-style/he...

clinicaltrials.gov/ct2/show...

Exenatide is a medication originally used to treat diabetes. Most of the forms of ataxia involve a buildup of "misfolded" proteins that cause cellular death. Parkinson's Disease and Alzheimer's Disease also involve "misfolded" proteins so they have this in common with ataxia. Where the proteins build up and which cells they impact cause different symptoms in these diseases, but again they all have one element in common: protein aggregates that aren't "cleaned out". The process of cleaning out proteins is known as "autophagy".

This is what exenatide researchers know about this medication:

"Cotreatment with the GLP-1 receptor agonist exendin-4 reversed the lysosomal dysfunction, relieving the impairment in autophagic flux and further stimulated autophagy"

"The study showed that intranasally administered Exendin-4 passed through the blood-brain barrier."

"These findings provide pivotal experimental support for further study of the neuroprotective effects and clinical application of Exendin-4.

In other words, this drug improves cellular function and helps it clean out bad proteins which is exactly what ataxic patients need. Whats best of all this drug has already had human clinical trials that showed promising results in treating Parkinson's and Alzheimer's. My recommendation is we all email the maker of this drug and encourage them to consider a clinical trial in people with ataxia.

One of the major trials in Parkinson's Disease is right there in the UK!

Cheers,

Joe

ncbi.nlm.nih.gov/pubmed/289...

ncbi.nlm.nih.gov/pubmed/282...

ncbi.nlm.nih.gov/pubmed/266...

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neta profile image
neta

Bravo for your research N

lola261184 profile image
lola261184

Do you have email we could email to

simon111 profile image
simon111

Hi Joe

Grasping at straws here any benefit for Friedrich 's ataxia

sunvox profile image
sunvox in reply to simon111

Hi Siimon,

Obviously that is a question best answered by your sons doctors, but my educated guess would be "no" this is not likely to help FA because FA is the result of the body's lack of a protein versus the production of a bad protein.

I will say if I had a child with FA I would be in the doctors office with all the research in hand relating to vitamin B, Thiamine, and the latest research on Niagen. Plus I would put together a list of options from the FA research summarized on CureFA.org and try to come up with a combination of ideas to use like in this study of Alzheimers:

ncbi.nlm.nih.gov/pmc/articl...

I wish with all my heart I could do more to help. Best wishes and prayers.

Joe

PattiTilden profile image
PattiTilden

Yes, good research!

simon111 profile image
simon111

Hi Joe

I actually have my son on thiamine, it has shown some benefits. I have been fighting a losing battle to get hI'm on interferon gamma.

Thank you for your good wishes and especially ur prayers

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