I've had Asthma since I was 7, which has got much worse over the last few years (now 39), and is now classed as ""Difficult Asthma"". I'm taking medication at Step 4, with frequent courses of oral pred to control exacerbations, (all prescribed by a Respiratory Consultant). I've just had a severe exacerbation which landed me in A&E three times in week, (low O2 sats, sky high resp and heart rate), which ended up with ABG's etc and a trip into resus. I was sent home on all three occasions, even though I had already been on oral pred for 5 days, which was not having any effect! Eventually had my steroids increased form the ""standard dose"" of 30mg, which did calm things down. My Consultant then decided to do a mannitol challenge, which was done five weeks after the exacerbation whilst I was still taking oral steroids and was completely symptom free, so not surprisingly it was negative. I also had normal spiro at the same time. I'm now being told that asthma was not the cause of my symptoms, despite A&E being certain that they were due to severe asthma. I'm now really confused as to why I am still taking all this medication for something the consultant has now decided I haven't got! Now back to the usual coughing, wheezing and being breathless because I'm off the pred. Has anybody else come up against this?