I have been on Uniphyllin now for almost 2 months, 300mg twice a day, this was added to my medication as I have had a really bad few months, but Im not sure if its agreeing with me and my other meds. I am on a Subcut Brincanyl Infusion, Seretide 250 inhaler and Salbutmol nebs etc. Has anyone else found problems with Uniphyllin I feel sick, have palpitations and general ""not feeling good"". Any help or advice would be great.


5 Replies

  • Sorry to hear it's not making you feel good!

    I've been on 200mg twice a day for about a year-ish. I did feel sick (and sometimes was), and had palpitations more frequently at the start. I'm on seretide too, so I take the two of them together, but I'm afraid I don't take bricanyl! I take it with a couple other things though. I think I know what you mean about the general ""not feeling good"" since I started the uniphyllin. That still comes and goes with me a bit. Have they taken bloods to check the level of uniphyllin in your blood? I think they do that fairly often with theophyllines; they did it with me after a while. As far as I know that can sometimes lead them to tweak the dosage a bit depending on how your body absorbs it. Sorry if they've done that already - just an idea.

    Caffeine doesn't seem to agree with me since I started that either - tend to get sick and have palpitations (like you say) if I take it.

    If it helps, the only other thing I was told was to take it 12 hours apart. I stick to that pretty rigidly with alarms on my phone, rather than just getting up/bed-time - if I don't I tend to feel a bit yucky.

  • Hi crookie,

    They can make you feel sick for a while,

    you usually need regular blood tests done to make sure you dose is not to

    high and become toxic and start getting reactions.

    I take one morning and night and can double up on action plan but after a week get realy

    nasty headaches then have to reduce them againxxxxx

  • Hi,

    I'm intereseted in this post as I had a first really bad flare up of asthma in early December which still hasn't been stabilised fully as yet. I went from being on no meds, no inhalers etc to being on prednisilone 60mgs, seretide 500 twice a day, combivent nebs and singulair. Then just before Christmas my GP suggested I start on uniphyllin 200mgs twice a day to get better control. I am aware of the side effects and really wasn't that keen given that this was my first serious flare up. So I held off. Talking to my GP tonight he was ok with this decision for now and I'm due to see a Resp sepecialist next week. Sorry I've nothing to add to the discussion to enhance the uniphyllin information. But thanks for raising the topic as I've been mulling it over myself! I am very new to this and just joined the forum today after searching for info on-line the past week or so about uniphyllin.

    The best of luck with your treatment and hopefully the side effects will ease as time goes on, but I second the other poster in saying make sure your blood levels are checked regularly and keep your dr informed of any effects you may notice.

  • Thanks for the replies and advice I am going for blood tests today and will stick with it for now.



  • I had a chat with my GP who informed me that Uniphyllin is the same family of drugs as caffeine. That's probably the reason why you're feeling jittery. A blood test to see if your liver is processing it properly would help.

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