Hi I know it has been ages since I have been on line. Marriage break up and move of house twice has absorbed all my time along with my son. We have been trying for omalizumab (Xolair) but now his IgE is out of range, so there is no joy there. He is not responding to IV Amonophollin,Steroids no longer work, nor his Terbutaline sub-cut. and consultants are suggesting Methotrexate. I know that this is an old drug and is used for the treatment of cancer, but has any-one any 1st hand experience of this?