half-dose prolia study

[MayGodBlessYou]

i'm interested in this,

has anyone run it by their prescriber?

low-dose prolia / dr Aliya Khan

academic.oup.com/jes/articl...

it reports favourable results

[MayGodBlessYou]

now i'm not so sure about this idea. i really really like the lower dose so that it's not so harsh on the body.

but the 30mg is the same level as roughly one month (25 days) into a 60mg dose,

as the half life is 25 days.

so wouldn't the level of 30mg at 5 months be the same as 60mg after 6 months?

so if the next 30mg dose is at 6 months, it's almost like having a 1 month+ holiday.

simply not sure that's a good idea?

wouldn't a 30mg dose then be better redosed at 5 months?, to stick to the schedule.

similarly a 15mg dose every 4 months.

so now i realise that the conventional dosage is only established to work around a twice-a-year schedule... for convenience.

because an annual dose, if the half-life is 25 days,

would need to be over 2320mg,

(calculated by doubling mg every month)

so, as much as i applaud dr Aliya's team investigating this dose,

maybe it could be workable at 30mg / 5 months,

equivalent to the usual 60mg/ 6 months, yes?, but kinder on the body.

the study starts with 183 people,

and it ends with 65 people.

what happened to 118 of the people?

did i get that right?

not that i side with the conventional studies,

which also have people missing or excluded from the study groups,

and can be sponsored by the manufacturer.

it occurs to me that doctors dont know what to do except keep administering,

or, they do know, and know that mainstream alternatives arent much better. so they're just administering to avoid fractures.

overall this is the ruination of many lives.

so i'm at a forgiveness process. where i forgive the endo, g.p, manufacturer, pharmacist, liars, scaring people into getting the drug.

i think the gp's are just dragged into using at as a treatment, handed a marketing brochure, without full disclosure by manufacturer of ill effects.

may God have mercy on their souls.

forgiveness doesn't mean that what they've done is ok,

it means that what they've done is definitely not ok,

and handing them over to the Lord,

thanks unto the Lord

[Raleigh59 in reply to MayGodBlessYou]

tried to understand what you wrote but I think you are saying regular lower usage is better. I actually read research study results last night that shows higher improvement from daily oral fosamax than weekly pill. So I definitely believe smaller regular increments gives better results. Oh I also heard about this from my pharmacist that the drug companies have high drop out rates so they do long time release medicines, to maintain people’s compliance they do monthly or 6 month or yearly to maintain compliance.

[MayGodBlessYou]

all up, theoretically, a 30mg dose every 4 months might have same or better effect than the 60mg twice a year, as it's not so harsh on the body. also easy to schedule.

and i don't know why i'm thinking any further about it as i can't agree with any administration of it,

there must be better ways, to say the least.

i've seen some terrible spin on some of the ill effects, that i can't even repeat.

may there be honesty in all studying and reporting.

[MayGodBlessYou]

furthermore!, i have read the the larger the gains in BMD while on prolia, the greater the occurence of the 'rebound' [prolia-induced] fracture injury that results after prolia cessation.

all the more reason to trial something like 30mg / 5 months doses,

which might result in less extreme gains of BMD.

i don't know.

but that was one of the aims of the Canadian trial,

to mitigate possible adverse effects,

so i think it could be useful in moderating massive bone loss that occurs when prolia is discontinued. it could make for better results when switching treatments. might even make combination treatment more workable.

in the main prolia paper, there's a line graph of gains on prolia compared with 2 other treatments, showing prolia way above the other drugs - as though more is better.

no, i don't agree,

extreme is not good,

and as it turns out, unsustainable and grievous when a dose is delayed or stopped;

the prolia-induced post-cessation fractures are as extreme as the 'gains' that had been produced.