Hi everyone I'm new to this site and wondered if anyone has had any side effects from blood thinners. I had a PE in March and have been taking Rivaroxaban since. At first I had quite bad vertigo and headaches but after about 6 weeks they gradually got better. But over the last couple of weeks I have developed a feeling of intense heat in my upper abdomen and chest which is very unpleasant (it's not acid reflux). I went to see my consultant and he suggested I take an alternative anti-coag. He mentioned Edoxaban or Apixaban. After reading up about both drugs I think I favour Apoxiban. But I'm worried about taking two tablets a day instead of one. I also have an occasional drink of wine in the evenings and am worried about taking the evening tablet whilst drinking wine.