It is not only learning from existing examples, it starts to see the underlying reasoning. I have taken a test that I have originally learned from Wes Roth...I have made it a bit harder, introducing useless noise in the form of irrelevant info (so it's not something it could have seen before in this form). The AI passed the test, even if I have written it in Italian. Till weeks ago (not even months) it would not have been able to pass it.
A pity that ADT made me forget another harder puzzle that I wanted to ask it to solve! But it will come back!
Translation of the test (note, I have added the cardigan because in my mind I started to look like Hugh Hefner)
Question:
I'm in my study. I'm wearing a dressing gown and comfortable pants. Under the gown, a cardigan. On my left wrist, I'm wearing a watch with a leather strap. I'm wearing a pair of comfortable slippers.
I pick up a teacup, the cup contains a golf ball. In my right hand, I'm holding a book. I move from the study to the living room without ever putting down the cup or the book. While walking down the corridor that connects the study to the living room, it occurs to me that I have an appointment. I look at the watch, I see that I'm not late. I proceed and arrive in the living room. Where is the golf ball?
Answer:
The golf ball is in the corridor. When you looked at the watch on your left wrist, you were holding the cup with the ball in your left hand and the book in your right hand. To see the watch, you probably had to move or tilt the cup, causing the ball to fall without you noticing.
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Maxone73
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This chatGPT has been saving me so much time searching for articles and answers to my questions. I love it. It actually answered a question that none of my doctors or geneticists answered is what gene mutation… well ill just post the question and answer.
Question:
What germline gene mutation can cause somatic MSH6-loss? Exclude germline MSH6 and show references
answer:
Somatic loss of MSH6 expression can be caused by mutations in several germline genes beyond MSH6 itself. One of the notable genes is **MSH2**, a partner of MSH6 in DNA mismatch repair. Germline mutations in MSH2 can lead to MSH6 loss, as these two proteins form a dimer necessary for repair function. When MSH2 is mutated, the stability of MSH6 is compromised, leading to its degradation and loss of expression in somatic cells [oai_citation:4,Next generation sequencing to decipher concurrent loss of PMS2 and MSH6 in colorectal cancer | Diagnostic Pathology | Full Text](diagnosticpathology.biomedc... [oai_citation:3,Frontiers | Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processes](frontiersin.org/journals/on....
Another gene associated with somatic MSH6 loss is **EPCAM**, where deletions at the 3' end of EPCAM can lead to epigenetic silencing of the neighboring MSH2 gene, indirectly causing MSH6 deficiency [oai_citation:2,Cancers | Free Full-Text | Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results](mdpi.com/2072-6694/12/7/1853). Furthermore, **MLH1** mutations, though more commonly associated with PMS2 loss, have occasionally been implicated in broader mismatch repair deficiencies, including MSH6 [oai_citation:1,Frontiers | Concurrent loss of MLH1, PMS2 and MSH6 immunoexpression in digestive system cancers indicating a widespread dysregulation in DNA repair processes](frontiersin.org/journals/on....
These examples illustrate how germline mutations in other mismatch repair genes, particularly MSH2 and EPCAM, can indirectly lead to somatic loss of MSH6 expression.
Now i took that and used my 23andme V5 chip and used a third party vendor which AI suggested and found a very rare MSH2 mutation not picked up in clinical genetics testing so AI suggest i confirm this mutation with a clinical lab test.
I will follow up soon, just got my boston Gene Tumor genetics done on my prostate tumor from back in 2015 and i have 8 mutations to research ti include ATM, TP53, MYC, and some others. I don’t know why Ambry Genetics somatic test back in 2020 never found those.
"I had radical prostatectomy followed by biochemical recurence. For three years now, I am on Bicalutamide dose adjusted as to maintain PSA less than 0.05. Currently, I am at 1/10 of the standard dosage i.e. 25 mg per 5 days instead of the usual 50 mg per day. Will the lower dosage extend the time to castration resistance or not?"
ChatGPT responded:
"The goal of managing hormone therapy in prostate cancer is to delay the progression to castration-resistant prostate cancer (CRPC). Bicalutamide is an anti-androgen medication often used as part of androgen deprivation therapy (ADT). The development of resistance to ADT, leading to CRPC, is a complex process influenced by several factors, including the duration and intensity of androgen suppression.
Lower Dosage and Time to Castration Resistance:
Lower Dosage Impact: Using a lower dosage of bicalutamide, like in your case (25 mg every 5 days), may reduce the intensity of androgen suppression. The theory is that a lower dose could reduce selective pressure on cancer cells, potentially delaying the emergence of resistant cell clones. However, clinical data specifically comparing low-dose intermittent therapy to standard therapy for the extension of time to castration resistance is limited.
Intermittent vs. Continuous Therapy:
Some studies suggest that intermittent hormone therapy may delay progression to CRPC and improve quality of life, but the overall impact on survival remains a topic of debate. Your strategy of reducing dosage might be analogous to an intermittent approach but is not the same as fully stopping treatment periodically.
Balancing PSA and Androgen Suppression:
By maintaining your PSA below 0.05 with minimal dosage, you are effectively suppressing disease activity while potentially minimizing side effects. However, whether this will extend time to CRPC compared to a standard dosage isn't conclusively proven.
Potential Benefits and Risks:
The lower dosage could theoretically delay CRPC development by reducing adverse effects and possibly allowing for a longer duration of hormone sensitivity. However, there's also a risk that suboptimal suppression might allow androgen-sensitive cancer cells to proliferate more readily.
Overall Considerations:
Individual Variability: The progression to CRPC is highly individualized. Monitoring PSA and other clinical parameters is crucial in assessing the effectiveness of your current regimen.
Consultation with Oncologist: Regular consultation with your oncologist is essential. They can consider your current PSA levels, side effect profile, and overall health status to determine if your current dosage is optimal or if adjustments are needed.
In conclusion, while a lower dosage might reduce side effects and potentially prolong time to castration resistance for some patients, it is not guaranteed and should be closely monitored under medical supervision".
The fun part is that if you read the chain of thoughts it created, it talks about "the most likely" solution...maybe I should ask the same question with a pocket watch???
No, maybe I should say something like "the ball is still in the cup. how is that possible if I rotated my wrist to check what time it was?"
I will past the experiment here, it was fun, I will paste only the last chain of thoughts it produced, otherwise it gets too long...but I have even read something about helium filled golf balls as option It got it right but I had to intervene with some hints.
Question: I'm in my study. I'm wearing a dressing gown and comfortable pants. Under the gown, a cardigan. On my left wrist, I'm wearing a watch with a leather strap. I'm wearing a pair of comfortable slippers.
I pick up a teacup, the cup contains a golf ball. In my right hand, I'm holding a book. I move from the study to the living room without ever putting down the cup or the book. While walking down the corridor that connects the study to the living room, it occurs to me that I have an appointment. I look at the watch, I see that I'm not late. I proceed and arrive in the living room. The golf ball is still in the cup, even if I had to rotate my wrist to check the watch. I have not put down either the cup or the book the whole time. How is that possible?
First answer:
t's possible because you were able to check your watch without tilting the cup enough for the golf ball to fall out. While holding the teacup with the golf ball in your left hand and the book in your right hand, you carefully rotated your left wrist to view the watch. By keeping the cup relatively upright or adjusting your grip, the golf ball remained securely inside the cup throughout the movement.
My answer
no, I have tilted my wrist more than 100 degrees, guess again
Second answer:
It's possible because the teacup has a mechanism or design that allows it to remain upright even when you rotate your wrist significantly. For instance, the cup might have a gyroscopic or gimbal design that keeps it level regardless of the handle's orientation. This means that even when you rotated your wrist more than 100 degrees to check your watch, the cup stayed upright, and the golf ball remained inside. You didn't need to put down the cup or the book because the cup's design prevented the ball from falling out despite the wrist movement.
My answer:
no, no mechanism or design to prevent it from falling, the ball is free to move, guess again
Third answer:
It's possible because you're wearing your watch on the inner side of your left wrist—the side facing your palm. When you rotated your wrist more than 100 degrees to check the time, you turned it outward in a way that kept the teacup upright. This means the cup didn't tilt enough to let the golf ball fall out, even though you rotated your wrist significantly. Since the ball is free to move and there's no special mechanism, the cup remained steady, and the golf ball stayed inside.
My answer (and first hint):
interesting solution but wrong, the wrist watch is on the outer side of my wrist. I am giving you a hint: the tilting amount does not count. Even if the cup was upside down, the ball would not have fallen.
Fourth answer:
It's possible because the opening of the teacup is smaller than the diameter of the golf ball. The golf ball is inside the cup but cannot fall out due to the size difference. Even when you tilt your wrist more than 100 degrees or turn the cup upside down, the ball remains inside because it's physically too large to pass through the cup's opening. The ball is free to move within the cup but cannot exit it, explaining why it didn't fall out even with significant tilting.
My answer (and second hint)
no, the ball is smaller than the opening. I am giving you another hint: I have two hands.
Fifth answer:
It's possible because you used both of your hands to prevent the golf ball from falling out of the cup. When you needed to check your watch, you momentarily transferred the teacup from your left hand to your right hand, holding both the cup and the book together in your right hand. This freed up your left hand, allowing you to rotate your wrist more than 100 degrees to check the time without tilting the cup. Since the cup remained upright in your right hand, the golf ball didn't fall out. You didn't put down the cup or the book at any point—you simply used both hands to manage them. This explains how the golf ball stayed in the cup even when you rotated your wrist significantly.
My answer (and third hint)
you are getting closer. But let's be more specific: my hands never left the cup and the book. They have been holding them the whole time.
Sixth answer:
It's possible because when you rotated your left wrist to check your watch, you brought the opening of the teacup into contact with the book you were holding in your right hand. By doing this, the book acted as a temporary lid, preventing the golf ball from falling out even if the cup was tilted or turned upside down. Since your hands never left the cup and the book, and you held them the entire time, the golf ball remained inside the cup despite the significant wrist rotation. This explains how the ball stayed in the cup without any special mechanisms or designs, utilizing only the items you were already holding.
Taking a closer look The assistant is piecing together clues from the conversation to redefine the puzzle hint.
Pinpointing the constraints
I’m thinking through the puzzle, focusing on the specific constraints of not allowing the ball to fall out of the tilted cup. This involves considering the exact requirements and constraints that must be met.
Revisiting assumptions
I'm thinking about how despite the cup's large opening and hand constraints, the golf ball stays in place. This suggests the ball isn't attached or restricted by the cup's shape, indicating an external factor is at play.
Considering gravity dynamics
I'm thinking through various scenarios, including the cup being upside down, anything sticky or solid inside, zero gravity, the cup being full of ice, and the ball being frozen or inverted over the golf ball on a table.
Analyzing scenarios
I’m piecing together the possibilities of how the ball remains in the cup when tilted or inverted. Ideas include a high-density liquid, a sealed cup, a magnetic attachment, or a double-walled cup.
Navigating the journey
I’m piecing together the scenario of a man moving through his home, holding a teacup with a golf ball and a book, without setting them down, despite tilting his wrist significantly.
Evaluating the scenario
I'm thinking it through: even if the cup's upside down, the ball stays put, supported by the inverted cup's bottom. He's holding the cup and the book continuously.
Weighing options
I’m examining different setups, like a sphere-shaped cup with a hole, a cup in a pocket, or a cup full of honey. Each requires careful consideration about mechanisms and constraints.
Investigating ball dynamics
I explored various ideas like the ball being too large for the cup, embedded in ice, or metallic and magnetic, but they didn't work due to the lack of mechanisms.
Visualizing the scenario
I'm piecing together the puzzle, noting that the cup could be upside down with the ball on top, and considering if gravity is affecting the ball in a zero-gravity setting.
Crafting a scenario
I'm thinking through how someone holds both a cup and a book. To check their watch, they invert the cup and use the book to seal the cup's opening.
Assessing potential movement
It's interesting to see that the cup's opening, held against the book, effectively kept the ball in place, even when the cup was flipped.
Chat Ai just added a picture mode. I asked it to produce a close-up picture of hands playing a guitar. It did a full-color illustration beautifully! Six fingers on the right hand and four on the left. I'm not sure I would rely on it for critical information.
Yes! Hands have always been incredibly difficult for AI to get right, even midjourney created incredibly beautiful pictures but horrible hands most of the time, but now Sora has no problems with them and it's not the only one. To be honest it also had problems with strings number last time I tried But that's another story, with images it's more a matter of imitation (or at least it was), the example I posted is a matter of reasoning, and this version of chat gpt also illustrates the chain of thoughts it made to answer. It's a huge step forward even compared to few months ago.
As I was reading your test story all I could think about as a kid I played a board game called Clue. Your test reminded me of that. Not sure if that board game is still around.
ball stayed in cup b/c you were in a low-gravity (or, free-fall, or zero-G) environment, wearing magnetized boots on a metal floor so you could walk. If low gravity environment, then you accelerated the cup just enough to match the downward acceleration of ball from the gravity, then skillfully turned the cup back upright, in a manner that cancelled the ball's movement.
yeah, that last bit is a hand wave...let's just keep it zero-G.
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It got it right but I had to intervene with some hints.
