NHS agrees to roll out Olaparib (Lynp... - Advanced Prostate...

Advanced Prostate Cancer

20,782 members25,886 posts

NHS agrees to roll out Olaparib (Lynparza) April 2023.

Sailing-Todd profile image
2 Replies

The NHS has agreed to Olaparib for advanced prostate cancer with mutations in the BRCA genes.

‘Hundreds of patients with advanced prostate cancer could benefit from a breakthrough targeted therapy after the NHS agreed a landmark commercial deal to roll-out the drug.

The drug, olaparib (Lynparza®), targets cancers with mutations in the BRCA genes, and works by stopping cancer cells from being able to repair their DNA by blocking a molecule called PARP, which causes the cancerous cells to die.

Around 550 men with advanced prostate cancer will be eligible for this new drug each year in England. In advanced prostate cancer that has spread to another part of the body, clinical trials have shown that olaparib, taken as a tablet daily, can extend patients’ lives by an average of six months – from 12 to 18 months – allowing them more time with their friends and loved ones’.

Written by
Sailing-Todd profile image
Sailing-Todd
To view profiles and participate in discussions please or .
Read more about...
2 Replies
HopingForTheBest1 profile image
HopingForTheBest1

I am BRCA2+, and was on Olaparib for 2 years (while only available in clinical trials prior to FDA approval, based on compassionate use). It worked well for 18 months with undetectable PSA.

My mutation then became "wild type", which meant it was no longer actionable

lcfcpolo profile image
lcfcpolo

This is good news. In the UK though, testing for BRCA is not routine. I would encourage all UK members to ask there oncologist to test them. Thank you for posting this.

You may also like...

Immunotherapy Clinical Trial or Olaparib (Lynparza)?

promising in those with the BRCA mutation, but only against a second ADT drug (the UK hasn't...

Testing for BRCA Mutations.

com/peer-exchange/prostate-therapy-review/metastatic-prostate-cancer-testing-for-brca-mutations [2]...

Experience with Lynparza (olaparib)

prescribing the PARP inhibitor Lynparza (olaparib) for me. This should be a match for my CDK12 DNA...

Approved for Lynparza (Olaparib)

doing it anymore, so Dr. Sartor has me going on Lynparza probably starting at my next appointment...

Men With BRCA-2 Mutation-How are you Treating/Doing?

of all Prostate Cancers---for those that carry the Mutated BRCA-2 Gene. Those with this mutation,...