I'd like people to share what supplements/drugs they are using. The more the better. We could all learn from each other.
This might not be clear. I made it in a word doc with tables and then had to butcher it up to add it to this post. Let me know.
Supplements and Drugs
Supplements are very unlikely to “cure” higher-grade cancer (T2-T4). However, in conjunction with other therapies, they might help control it.
When reviewing data for supplements it is important to view the results in context of this study:
ncbi.nlm.nih.gov/pmc/articl...
“in the RCT placebo cohort; 46% of patients experienced PSADT increases >200%”, “These data suggest that calculated PSADT in BRPC may naturally increase over time in the absence of therapy and may be influenced by duration of PSA follow-up. As a result, single arm trials could show false significant increases despite the lack of active treatment of these patients. Placebo-controlled RCTs including clinical endpoints are recommended to screen novel agents in men with BRPC to mitigate bias because of natural PSADT variability.”
To reduce the possibility of supplement contamination overwhelming my body I divided the supplements into groups A and B. I take “A” for a month, and then “B”, and repeat. (note: this was lost going from my word doc to this text - but just divide them up how you want and keep the best ones in both A and B).
Ratings are for PCa only.
Coffee: A few cups before noon (unless you are not sensitive to the caffeine and then you can take it anytime you like).To prevent caffeine habituation I drink this for a week or so and then stop for a week or two.
Green or white tea: (80% tea/20% lemon juice – lemon juice helps prevent kidney stones)A few cups before noon (unless you are not sensitive to the caffeine and then you can take it anytime you like).
I drink tea for a week or so and then stop for a week. If I don’t take a break, I get headaches.
Take the supplements with a 1 next to it on the first week
Take the supplements with a 2 next to it on the second week
Take the supplements with a 3 next to it on the third week
K- is stressful on kidneys
L- is stressful on liver
K+ might help kidneys
L+ might help liver
Example:
1, 2 = take this supplement during week one and week two but not on week three
When I take them:
A: Upon awakening on empty stomach
B: First meal.
C: Second meal.
D: Last meal.
E: About an hour before bed on empty stomach
Things in bold are my "core" supplements/drugs
Rx Optional: (K-) (L-) Phenelzine – antidepressant.
Some research on the combination of phenelzine and naproxen shows some potential.
If this is taken, take it on the same days as naproxen. 1, 2, 3, A 15mg, B 15mg, C 15mg, E 15mg
Lycopene: 1 oz tomato paste or 4 oz tomato-based pasta or tomato sauce 1, 2, 3
8 oz of pomegranate juice or pomegranate extract with 100 mg+ ellagic acid 1, 2, 3
Optional: vegans are frequently low on creatine since it is mostly found in meat.
Creatine monohydrate 1, 2, 3 5 grams before working out
Ferrous Bisglycinate (Iron)
Only take this if your TIBC, Ferritin, and/or Iron is low (most vegans) 1, 2, 3, B ~100%-200% of RDA
(K+) Vitamin K2 (MK4 and/or MK7) 1, 2, 3 B 100% of RDA
(K+) Vitamin D3. Target serum levels of 30-50 ng/ml. Higher is as bad as lower. 1, 2, 3, B 5kIU
Garlic bulbs
Crush these and let sit for 10 minutes or so before eating. The crushed bulbs last about a day at room temperature. 1, 2
Rx (K-) Metformin (if your fasting blood glucose is < 70 mg/dl you probably don't need this) 1, 2 A 500 mg, B 500 mg, C 500 mg
NovaSol Curcumin 1, 2 as directed
(K+) Sodium bicarbonate 1, 2, 3, A 975 mg, E 975 mg
(K+) Sulforaphane 1, 2, 3, A, E
From supplements as directed
OR
1 oz of home sprouted broccoli sprouts
OR
½ tsp of powdered broccoli seeds.
If using seeds or sprouts heat them up for a minute to 50-60 degrees C. Hotter than that destroys the active ingredient. I use a meat thermometer to check the temperature. 1, 2 All 30 mg 30 mg
Rx Finasteride – if you are following BAT take as directed in the program. 5 mg
Rx Dutasteride - do not take if you are doing BAT, otherwise: 1, 2, 3, B 0.5 mg/day
Child’s multivitamin
Make sure B-12 is from methyl cobalamin and folate is methyl folate.
Iron should be low, non-heme, or from ferrous Bisglycinate.
One example is “NATURELO One Daily Multivitamin for Men - with Vitamins & Minerals + Organic Whole Foods” 1, 2 2-3 days As directed
Optional and only if you are doing a statin or red yeast rice and notice muscle pain (extremely rare)
CoQ10
Might reduce statin cancer fighting effectiveness but might fuel Pca. So only take if you notice statin side effects (typically fatigue and/or muscle pain). 1, 2 2-3 days 100 mg
(L-) EGCG 1, 2 A 400 mg, B 400mg
Magnesium 1, 2 E 250 mg
(K-) Aspirin – cardiac protection (blood thinner) 1, 2, E 81 mg
Melatonin – Take this with a full glass of water. 1, 2, E 3 mg
Rx Lovastatin – cardiac protection (cholesterol reduction) 1, 2 E 40 mg
Red Yeast Rice – cardiac protection (cholesterol reduction). (as of 2022 HPF Cholestene was one of the only effective brands) 3 B 120 mg, C 120 mg, E mg 120 mg
(K-) Orlistat 1, 2, B 60
Meriva curcumin 1, 2, C, as directed
Theracurmin 1, 2, B, 300 mg
Rx Celecoxib 1, 2, B 200-400 mg
Optional: (K-) (L-) Naproxen
Most research indicates that naproxen isn’t very effective vs. PCa. However, some research on the combination of phenelzine and naproxen shows some potential.
If this is taken, take it with the last phenelzine dose. 220 mg
Cholestoff – cardiac protection (cholesterol reduction)
1, 3, B as directed
Once a week with a meal
* Rx Cabergoline 1, 2, 3
~0.5 mg or as prescribed
(or optimally 0.25 mg twice weekly) Reduces prolactin. Prolactin might be one of the primary “fuels” for prostate cancer.
* Rx Sirolimus 1, 2, 3
~2 mg or as prescribed Fat burning is increased if you exercise an hour or so after taking this.
List of all supplements examined. Ratings are for PCa only.
Note that this has been updated. Some scores have changed slightly based on newest data.
Evidence, dose
7.50 Zytiga 250mg
6.99 Diet Depends on the diet Depends on the diet
6.16 Exercise
4.78 Dutasteride 0.5mg
4.68 celecoxib/statin
4.41 Aspirin 81mg
4.18 EGCG 400mg
4.14 Pomegranate (100 mg ellagic acid in 32oz of pomegranate juice, whole pom juice and arils likely have other cancer fighters in addition to ellagic acid) 2oz
4.14 Lovastatin 60mg
4.06 Green tea 1 cup
4.03 Red Yeast Rice 3600mg per day. Must provide a total of 15mg+ of monacolin K. 3.5 possibly if contaminated with citrinin. C
3.93 Pravastatin 10mg
3.64 Vitamin D3 ~4kIU/day. Monitor serum vitamin D and target 30-50 ng/ml.
3.63 Metformin 500mg
3.50 Melatonin 3 mg
3.17 Sulforaphane 30 mg
3.17 MCP Tbsp
3.15 Lycopene 20mg
3.03 Curcumin/Turmeric/C3/Theracurmin: Biocurc and NovaSOL>CurcuWin>Meriva>BCM-95>Theracurmin (NovaSol Supposed to be good with 24-hour half-life, take in morning on empty stomach)
3.00 Prednisone 5mg (only if zytiga is used)
3.00 Children’s Multivitamin
3.00 Iron - Ferrous Bisglycinate 25mg
2.83 Garlic 2 Cloves
2.82 Aged Garlic 440mg
2.80 Algal oil or fish omega 3 oil (DHA, EPA) 1g
2.70 Cabergoline 0.25mg twice weekly
2.68 Valproic acid 500mg
2.62 Reishi Mushroom 1200mg
2.57 Magnesium Bicarb Blood pressure. Magnesium RDA is 420mg (2.5g of magnesium bicarb). Dose 1g
2.54 Beta Sitosterol 900mg sterols/stanols
2.38 Pomi-T Cap
2.34 Zyflammend Cap
2.33 Magnesium 500mg
2.32 Dim (Diindolylmethane) 225mg
2.30 Whey protein (30-60 grams a day)
2.29 Berberine 500mg
2.24 Vitamin K2 Mk7 Form 100mcg
2.17 Loratadine 10 mg
2.17 Nattokinase 2000 FU+
2.11 Doxycycline 50mg
2.06 Orlistat 60mg
2.02 Resveratrol 150mg-3000mg
2.01 Cocoa 1g cocoa polyphenols (approx. 20g cocoa powder)
2.01 Cacao 15g (mixture)
2.00 American Ginseng as directed
1.93 Itraconazole 300 mg
1.93 Creatine Monohydrate 5g
1.88 Ursolic acid
1.86 Sodium Bicarbonate 1-2g
1.84 Turkey tail (trametes versicolor) as directed or an oz or two of real mushrooms
1.84 Niacin 1g
1.79 Piperine 10mg
1.77 ivermectin
1.77 Rapamune (Sirolimus) 2mg
1.77 Ginger 400mg
1.76 Phenelzine 15mg
1.73 Korean (Panax) Ginseng as directed
1.69 Boswellia 500mg
1.67 Probiotic as directed
1.64 Potassium Bicarb Blood pressure. Potassium RDA is 4200mg (10g of potassium bicarb). Dose 5g dangerous if your kidney function is decreased.
1.64 Cinnamon 1g cassia or Ceylon with meals
1.59 Caffeine get from coffee primarily
1.57 Olive Oil 5-15g
1.54 Finasteride 2.5-5mg
1.53 Dukoral vaccine
1.53 Green Coffee Extract
1.52 Naltrexone (LDN) 5mg
1.52 Astragalus 5g
1.51 ALCAR
1.51 Spirulina
1.48 Boron 3mg
1.46 Potassium 99mg (hypertension experts rec up to 4.7g a day) dangerous if your kidney function is decreased.
1.46 L-Carnitine 1g
1.43 CoQ10 100mg
1.42 Vitamin E Delta Tocotrienol 150mg
1.38 Milk Thistle 760mg
1.32 Ip6 And Inositol 5g
1.31 Beta Alanine
1.30 Black Seed oil (Cumin Seed) (Nigella Sativa) TBSP
1.28 Ashwagandha 500mg
1.26 Blueberries 60-120g/day
1.26 HMB 1g
1.26 Pqq (Pyrroloquinoline Quinone)
1.26 Olive Leaf Extract 1g
1.26 Hydroxychloroquine
1.26 fenugreek
1.26 hibiscus tea
1.26 7-Keto DHEA 100mg
1.25 Eleuthrococcus Senticosous (Siberian Ginseng) as directed
1.23 Quercetin 750mg
1.17 Yohimbine 10mg
1.11 Tamoxifen 5mg
1.08 B12 methylcobalamin
1.05 Grape Seed 400mg
1.03 Nigella Sativa Oil 1g
1.02 Genistein 100mg
1.02 Elderberry
1.01 Holy Basil
1.01 Bacopa Monniere
1.00 Bromelain
1.00 Mebendazole 100mg
1.00 Colostrum
1.00 Citrulline Malate
0.79 Lecithin 1g
0.78 Wheat Germ Oil 1g
0.78 Pterostilbene 500mg
0.77 L-Taurine
0.77 Stinging Nettle - reduce SHBG 3mg
0.76 Peppermint oil (menthol)
0.76 Theanine
0.63 Alpha Lipoic Acid
0.50 Fulvic Acid
0.48 Pregnenolone 100mg
0.43 HCA 250mg
0.26 Sea Buckthorn Oil 1g
0.24 Niclosamide 10-3000mg 1-3x a day
0.21 Ibuprofen Opposite Days from Aspirin
0.16 Artemisinin 200mg
0.14 Fisetin 100mg
0.13 Red Wine
0.13 Celastrol
0.11 Astaxanthin
0.10 Black Cohash
0.09 Naproxen 200mg
0.08 Indole 3 Carbinol (I3C) 81mg
0.06 sulindac
0.05 Prebiotic Mix (Psyllium, Inulin) 15g (mixture)
0.04 Aprotinin
0.03 fenofibrate
0.03 PMSF
0.02 Cimetidine 200mg
0.02 Bestatin
0.02 Pepstatin
0.02 Avena Sativa
0.02 Beta 1,3D Glucan
0.02 Mistletoe
0.02 Strawberries
0.01 Azithromycin 125mg
0.01 Prostacaid
0.00 Flax Oil 1g
0.00 Fenbendazole 222mg (1g Panacur C)
0.00 Leflunomide
0.00 B Vitamins
-1.00 Nad+
I got tired to compiling data for things that don't pass first screen. So I started just listing them. Supplements that are not summarized. Ratings are for PCa only.
None of these passed initial data analysis.
No positive RCTs
3-bromopyruvate lemon balm
acetazolamide retinoic acid
ahcc Tamoxifen
apigenin Propranolol
asparaginase pde-5 inhibitors (sildenafil is possibly best for ED and possible treatment)
baclein doxorubicin serious sides
betulin Disulfiram possibly 1 positive clinical trial
biobran intravenous vitamin C data is inconclusive
black chokeberry
butryric acid
capsaicin
cat’s claw (uncaria)
chito-oligosaccaride
chromium
chrysin
clemastine
cordyceps
cyclocreatine
dan shen
dichloroacetate 1 null
ellagic acid
fermented wheat germ extract
feverfew
gambogic acid
graviola
gymnema silvestre
haritaki
honokiol
juglone
Kaempferol
kava kava
lactoferrin
memantine
mildronate
naringen
nexrutine
Nifuroxazide
nimolide
Nordihydroguaiaretic Acid (NDGA)
oxymatrine
papaya seeds
paw paw
pentoxifylline
polydatin
proanthocyanidins
rabdosia
raloxifene 2 null
rhodiola
scutellaria baicalensis 1 null
siegesbeckia
Stevia
sulfasalazine
tetrathiomolybdate
thc
triphala
vigna
watercress
xanthohumol
OK so what if any supplements/drugs protect cognitive function during ADT? 
Supplement - Ganocellium
Juicing? Supplements?
Beneficial supplements?
Wooh! That's quite a list. Like many of us dealing with PCa, I did exhaustive research trying to determine the most likely supplement combo with the highest likelihood of being that "Silver Bullet" Bottom line is no one has found it. There's not enough money to fund long-term well designed studies on all the neutraceuticals as most don't provide high profit potential for Big Pharma - although the supplement industry is making a killing (billions) since they can make all sort of claims based on weak/poorly designed studies. I don't think I know a single person that isn't taking some sort of supplement, most of them a systemic meta-analysis of studies (if it exists) shows questionable benefit. There are some gems in the rough of course.
By far, good diet, lots of exercise and stress reduction are the combination that probably has more of a significant synergistic effect than pretty much any supplement combination you can dream up. I do a Medditeranean Diet that is 80% Vegan and like to cook and don't miss the hamburgers but I'll have a big burger every couple weeks as a treat or BBQ chicken. Also going on a lipid based statin (like Simvastatin) has pretty good data.
Personally I chose a few supplements that are not overly expensive that I was confident can do no harm. I alternate between Rhodiola Rosea and Coq10 (200mg) every other day, the former is an adaptogen/anti-oxidant I took before my PCa diagnosis that helps with stress/energy and I've had far less colds and no cold sore outbreaks when I take it. The latter I take to insure against Coq10 depletion from the Simvastatin I take. In general I'm trying not to overdo it on antioxidants as too much can also help cancer survive better. I also take Omega-3 supps (fish oil, avoid too much ALA Omega-3, get DHA/EPA - I take 750 mg total EPA/DHA a day) and use an app that has an NCCB database with Omega content of foods so I can shoot for a 2 to 1 Omega 6 to Omega 3 ratio which is about 1/10th the ratio of the average American diet at 20 to 1. And finally I try to maintain Vitamin D levels between 45 and 70 ng. There is strong evidence too little or too much Vit D is bad for PCa. This requires from what I understand somewhere around 2,500 to 5,000 IU a day depending on how far North you live, season, and and how often you get out in the sunshine. This is one thing you want to test once or twice a year for to dial in how much you need. And finally due to the mostly Vegan Diet I take low dose Calcium+Magnesium+Zinc supp (333-500 mg Calcium 2 + 150-250mg Mag + a little zinc) and Vitamin K2 daily. All of those you can easily miss the mark on if you are going Vegan unless you go out of your way to eat foods high in those minerals (usually fortified.) Too much calcium not good for the arteries though. I get most calcium from fortified foods (bread, non-dairy yogurt, calcium processed tofu) That's it. Was tempted to do Sulforaphane, Modified Citrus Pectin, and a lot of other stuff but I'm not going that far unless I end up with significantly rising PSA.
Exercise appears to be king. Diet is second. Statins are #3. I tried simvastatin and a few other statins but they gave me terrible insomnia (a rare side effect - but if it hits you it's 100%).Lovastatin is fine for me. Maybe interferes with my sleep a little but not enough to stop taking it.
I tried to remove subjectivity from the rankings. I doubt that I succeeded 100%.
I have a rather complex weighting formula that includes data sources:
1. care oncology
2. some BAT and SPT MOs
3. examine.com
4. consumerlab.com
5. my MO
6. my own test data
7. cancer.gov
8. PubMed trials
9. PubMed 5-year trials
10. PubMed hits
11. PubMed 5-year hits
12. PubMed 5 yr/all-time hits and Pubmed 5 yr trials/all-time trials - shows kind of a heat map.
13. Government-regulated RCTs
(getting all the data for all of these drugs and supplements took hundreds or thousands of hours over the last 4 years)
I weighed the government RCTs very high. Cancer.gov was also rather high.
On any given day I only take about 10 drugs/supplements. I took more at one time but my kidneys were failing so I cut back a lot.
Some are specific for certain conditions. And some are likely synergistic but do not pass on their own. So, is my list perfect? No. It's a stab at putting some order in my supplement/drug chaos.
If you notice I take a few that aren't ranked highly. Sirolimus for example. Not a bad ranking but not in the top dozen. Blocking mTOR is something that I think might be important when on the ADT portion of BAT.
I didn't highlight finasteride even though I take it and not dutasteride during the ADT portion of BAT. For most guys, the long elimination half-life of dutasteride isn't going to be an issue. And it blocks 80-90% of DHT whereas finasteride only blocks about 70%. 2 avenues vs. 1.
Super, this is so helpful. Ranking your references is especially valuable when we're all facing information overload. You have really researched these things and I'm going to save this post as a reference. I posted what I'm taking and why but it's not nearly as comprehensive as what you have done.
👍
"I'm trying not to overdo it on antioxidants as too much can also help cancer survive better" I am curious if this statement is based on a reliable study?
Depends on what antioxidant or combination I suppose. Many years ago they thought Vit A + E would help protect against cancer but later found it made lung cancer more likely.
tcr.amegroups.com/article/v...
Here's an example regarding breast cancer (also posted by smurlaw) regarding Breast Cancer as another example of antioxidants not always being beneficial.
pubmed.ncbi.nlm.nih.gov/318...
Super and well written' I agree we need to do research.the Vit D3 is fantastic for cancer and general health. as you said around 60 Nanogram's per milliliter
Thant would be about 4000IU (international Units) of the vitamin per day........statins and other drugs tend to deplete it.
I also believe in Beta Glucan. We use the extra strength by NSC corporation. Beta Glucan modulates your immune system and does not" rev" it up or bring it down as we all need something different in that area.
As I have suggested in one of my posts: exercise for oxygen, diet (no sugar), sleep, water (keeping hydrated), a happy attitude...........and Hope
The vit D and Beta Glucan do wonders...........
thank You for your time
LRV
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