Perhaps try estrogen patches if CRPC ... - Advanced Prostate...
I am using oral DES, which was standard treatment for decades before Lupron.
Yes, there is a risk of unwanted coagulation, but nattokinase eliminates that. I check D-dimer periodically.
DES is cheap - <$50 for 90 day supply.
DES is synthetic, but is recognized as an estradiol equivalent for bone health.
DES seems to have ab anti-PCa property unrelated to its effect on testosterone [T]. Indeed, I know of two men using low-dose DES where T is unaffected. Both men have fairly high T for their ages. If only ...
Does DES have anti-PCa properties that patches don't?
"DES has at least three mechanisms of action in the treatment of prostate cancer in men. It suppresses gonadal androgen production and hence circulating androgen levels due to its antigonadotropic effects; it stimulates hepatic sex hormone-binding globulin (SHBG) production, thereby increasing circulating levels of SHBG and decreasing the free fraction of testosterone and dihydrotestosterone (DHT) in the circulation; ...
"... and it may have direct cytotoxic effects in the testes and prostate gland. ...
"DES has also been found to decrease DNA synthesis at high doses."
A petmed site? Or can an NMD get it - maybe compounded? My NMD gets me all sorts of stuff.
Yes, a comment or two on suggested sourcing would be nice.
The only things I found for oral DES are pet med sites and research labs (they charge $1000s of dollars).
Estrogen patches (e.g. Climara) can be obtained from your local pharmacy if you have a script. You can get a month's supply of 0.1 mg/day patches for about $20 through goodrx.