Your views please

[Farn]

How long do you think before stage 4 becomes a manageable chronic disease giving near normal life expectancy using a suite of drugs

[Hidden]

Not in our lifetime. I have accepted my death from cancer and have made peace with the very few people who surround me. Everyone else can go to hell, I will see them there.

Note: I'm not a doctor.

[Shooter1 in reply to Hidden]

With my 2nd BCR in high gear right now, well Life Has Been Good....

[Hidden in reply to Shooter1]

Amen, the light at the end of my tunnel is glowing brighter. Strange as it sounds I'm drawn to it.

[Grumpyswife in reply to Hidden]

My husband may be thinking like you. He is tired of it all. However, he is not a gifted communicator like you.

[CAMPSOUPS in reply to Hidden]

In 1980 my wife, a foreigner, and I moved into a new neighborhood and a neighbor lady kept trying to convert my wife to her religion.

She told my wife that she would go to hell. My wife said her grandparents must be there then so that’s where she would like to go too.

[Hidden in reply to CAMPSOUPS]

I had someone sitting next to me try to convert me on a flight.

I suggested to her the possibility that maybe she will go to her version of heaven based on what she believes. And what if I were there outside of her closed-in reality and tried to tell her that there is much more beyond it and everyone outside of it is not in hell? She said she wouldn't believe me. She would think it must be coming from the devil or something along those lines.

So I really want to make sure I stay out of her version of heaven.

[CAMPSOUPS in reply to Hidden]

On a flight no less. That's real dedication lol.Nice story.

Her version is a nightmare. Not safe in heaven. The devil is knocking on the door lol.

We better knock it off. Religion and politics. I don't want to see it here and I burped it out myself.

I just wanted to comment based on nameless's comment. I didnt know what to say and ended up with that for some reason.

[tsim in reply to CAMPSOUPS]

Reminds me of the French writer Voltaire, when asked on his death bed if he would renounce Satan he said "this is no time to be making enemies"

[CAMPSOUPS in reply to tsim]

Love it. That's hilarious.

[monte1111 in reply to Hidden]

I shall see you sooner or later. Let's hope j-o-h-n isn't there.

[Hidden in reply to monte1111]

LOL! If he is present I'm going to jump in the first fire pit I see.

[Kevinski65 in reply to Hidden]

At least u can warm your hands, take up baking...

[Hidden]

I do not know, but I can say this much. Things move faster in the PCa world than they do in the Type 1 Diabetes world. My son was diagnosed with T1D about 10 years ago and the state of affairs there is seemingly slow progress. On the PCa side there seems to be a ton of energy around immunotherapy. There was a member here talking about Amg509 (healthunlocked.com/advanced... and has been seeing terrific results. I asked my MO about it and he said that how we deal with PCa in 5 years is going to be dramatically different than how we deal with it today.

[ExPat193 in reply to Hidden]

There is no profit in cure but in continued treatments

[DanHo in reply to ExPat193]

Whomever finds a cure will have a never ending money printer

[ExPat193 in reply to DanHo]

They have that now.

[TJGuy in reply to Hidden]

You should recheck type 1 and type 2 diabetes treatments in clinical trials overseas, recent developments in both of those have shown remarkable results. While trials are ongoing cures have been claimed.

[Hidden in reply to TJGuy]

Interesting. Can you tell me more?

[noahware in reply to Hidden]

I hope you look into the area of using diet to manage T1D. I have a distant friend with a son that has it, and they have pursued extreme low-carb with good results for years (can't give you details, but do know his need for insulin shots is far lower than many). As I recall, his fruit intake for example was pretty well limited to raspberries and blackberries, maybe one or two others with very low net-carbs and high fiber. Verging on a keto diet, maybe? (Not to be confused with ketoacidosis!)

I think the basis for a lot of current thought in this area was "Dr. Bernstein's Diabetes Solution." The original publishing was about 25 years ago, so I suspect there have been some refinements and caveats (by him and others) regarding his original protocols. Ever heard of it? Might be worth checking out.

[CAMPSOUPS]

I think sszyszkiewicz covered your question well.A lot is going on. Immunotherapy beyond what is currently available from Car-t to enhancement of RNA research stemming from research around the covid vaccine.

Many other treatments in the tunnel to emerge.

Some on my medical team mentioned the 5 year scenario. If I make it to 5 years there will be more treatments which will then give me a chance at another 5 years.

[mrscruffy]

I have faith there will be a cure in my lifetime(better hurry up) just in case, my affairs are in order and I am living like a rockstar

[CAMPSOUPS in reply to mrscruffy]

I keep forgetting who mrscruffy is. But when you end with living like a rockstar I go "oh yea that's the guy with 2 women in his bed" lol.

[mrscruffy in reply to CAMPSOUPS]

Yes I am

[lincolnj8 in reply to mrscruffy]

Love it. My feelings also

[Hidden]

I think a lot of progress has been made, but we're a long way from a chronic, manageable disease for most. Too many are diagnosed with stage 4 at an early age, well before their normal life expectancy. It's just too far of stretch for them given the current available treatments. There are some guys who become recurrent in their late 70s or 80s and do end up with something that's manageable and die from something else.

[CAMPSOUPS in reply to Hidden]

Yea chronic, manageable rings of take a pill the rest of you life and your set for no progression.Even our emerging treatments seem to be of the "this should last awhile variety".

Long term PFS (progression free survival) is our goal coming in at several months to several years before we need to seek another treatment.

[Hidden in reply to CAMPSOUPS]

When I thought about this question, the progress on AIDS came to mind. Having AIDS was pretty much a death sentence early on, but today AIDS patients have life expectancies similar to everyone else. This has been a fairly recent devlopment.

Of course, stage 4 anything cancer is a different story. I know I'd be happy with any additional time I could get with the treatments that have become available in recent years.

[Hidden]

Given the wide range of disease states within stage 4, this is a difficult question to answer. For those who are stage 4 and not M1, hitting the cancer hard early has shown incredible results. Those with low volume mets also have positive results, its the men with high volume mets, especially involving the bone, that are the most difficult to treat. Hopefully newer treatments will help this group sooner than later.

[Howard53545]

It will happen

[noahware]

It already is that, for a very small percentage of men. Rather than a sudden silver-bullet switch where ALL men get to a manageable chronic disease state (giving near normal life expectancy) I expect it will be a continual and gradual evolution, from fewer men towards more men.

Even after many decades of advances and such increases, in turning PC from lethal to "chronic" for many men, I would think there will still remain a subset of men with lethal, aggressive, mutating cancer that simply can be slowed but not stopped. Hopefully, that subset gets smaller and smaller.

[j-o-h-n]

youtube.com/watch?v=WOYzFKi...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 02/19/2022 12:55 AM EST

[lincolnj8 in reply to j-o-h-n]

Oh could he dance. So graceful. Great post..

[TJGuy]

Of I were a betting man I'd put a few percent hedging on the long shot of chemicals beating or holding down cancer.

But I'd bet a whole lot more on CRISPR and mRNA being able to do the job.

I believe that attacking the cancer directly by altering it's molecular composition (knock out, replace, or insert genes in the cancer itself) will eventually win the day.

I think the tools and the awareness of the tools and approach has just come into widespread conciousness as a "Eureka" moment.

I believe money is suddenly pouring into this research around the world.

I think the men in their 30s and 40s will face a far different future with PC. For us who all ready have it, we can only hope the results come quickly.

Cancers are distinct dieseses numbering in the hundreds. That a lot of curing and trials to be done. PC is just one of them and it is a tumor type not a blood type so it's been historically harder to reach.

[larry_dammit]

I have to agree😢. I don’t think it will be in my lifetime, 66 months into stage 4 with Mets.

[Kittenlover50]

Stage 4.. in lymph in chest. For us it has. Started with chemo, then Lupron and zytiga 6 mo, then 37 radiation with meds then meds a year. Non detectable and no evidence disease 5.5 years, no cancer meds or treatments 4.5 years. Yearly pet scan,MRI, PSA 3-4 times a year. The PEACE1, including CHAARTER and STAMPEDE studies are paving the way.

[SteveTheJ]

IMHO anyone who purports to know an answer to that question is a fraud. No one can possibly know that. I was diagnosed with stage 4 cancer since March 2020. Things are fine so far with ADT. However, a man diagnosed a year before me is now dying. Who's to say why? I'm not that familiar with his treatment so maybe his medications didn't work as well, maybe he stopped taking them, I'm not sure.

Buck up. Get the best advice from the best oncologist you can find and strap yourself in for an unpredictable future. Read this list; I believe there are men who have survived stage 4 prostate cancer for decades. Inform yourself and realize that worry is useless. You have to look forward and be realistic.

[swwags in reply to SteveTheJ]

I dunno. I think the question is reasonable and banal. I don't believe anyone said they knew the answer. It's going to be very different from each person in this post and unless you are an actuary, you're prolly going to be wrong anyway. Plan on living. Focus on living. Worry not about what you can control. Worry not about what you can't control. I have no intention of dying from my cancer. I hope I'm right. My answer to Farn is yes, I believe stage 4 will become a chronic manageable disease in my lifetime. Given there are several guys on here living 10+ years with it is sort of the definition of chronic, is it not?

[Poowater]

It is already just a chronic disease for a great number. For all, it depends on how the disease has progressed. Everyone, has a unique experience.

[NecessarilySo]

I'm optimistic. Twenty years.

[addicted2cycling]

WHY ON EARTH would one want to be in an existence for eternity *what ever that is* with everything perfect. BOARING!!!!

I am looking forward to being dead to this World and the NON EXISTENCE following death. Now that's *eternal peace*.

[Farn in reply to addicted2cycling]

Eternity ? I was thinking more into my seventies

[Hidden in reply to addicted2cycling]

Did you purposely misspell BORING or do they call getting run over by a wild pig BOARING!!!

[addicted2cycling in reply to Hidden]

YES, I got hit by a wild pig while bicycle riding April 27, 2020 at 1:25AM at mile 34 of a 100 mile long planned ride that night and wound up in a trauma center with 2 cracked ribs, punctured lung, cracked scapula and trauma to my left shoulder that weekend the area helping to cause a Rotator Cuff tear on July 4th last year from another bicycling mishap at mile 100 of 102 during my 4th Celebration Ride. I intentionally making spelling errors butt only at certain times.

p.s. - bicycled 121 miles yesterday to challenge myself as a 71.5 year old castrated Gleason 10 fool who chose a never tried treatment protocol back in 2015.

[Hidden in reply to addicted2cycling]

I knew about the run in with the 🐗. I wasn't sure if you purposely misspelled or were being funny. Now I know..I think?

[Hidden in reply to addicted2cycling]

Yours is an incredible result but you wouldn't be selling your outcome for everyone. Also, age is a huge factor...I was 53 when dx'd a daughter in HS. I'm looking for as much good time on this earth as possible. I'm doubtfully the treatment you chose would turned out as well for me.

[addicted2cycling in reply to Hidden]

Totally understand and agree!! What I find interesting AND POSITIVE is that Dr. O has continued on AND EXPANDED on what I received resulting in positive results for some men. Hoping my journey, unusual as it maybe has helped to lay a foundation for beneficial treatment for others.

[SteveTheJ]

I was told by 3 oncologists that I have 3 to 5 years to live. I didn't believe them but you never know. That's one reason why I'm in this group: to learn from others.