Schwah, one of our members asked me what is CAR-T-->so I decided to post for all to read. CAR-T---CELL THERAPY is an immunology technique. This technique can sometimes be referred to as [Adaptive Cell Therapy].
Basically, T cells from the population of White Cells are extracted. They usually go to a specialty Pharmaceutical Co. And to these T Cells, an Artificial Receptor[referred to as a *chimeric antigen receptor] is added to the surface of the T Cells. The modified T Cells are then returned to the patients' bloodstream. This new entity in the blood produces chemicals that kill cancer cells. They multiply and they attack cancer tumors. This technique has been approved for years by the FDA for Hodgkins Lymphoma and Childhood Leukemias. Now CAR-T has been around for years and the old versions that failed with other cancers did so because they all targeted the same CD-19 Molecule on the surface of the cancer cell. Failure occurs when the Cancer Cells in a Tumor mutate and shed their CD-19 Molecule-->leaving the CAR-T without a target. So years went by and CAR-T fell quickly out of favor. Some people got help and cured--one such person was put on the cover of the Sunday Parade Magazine---who had 4th Stage Breast Cancer and was cured, Period. I never heard of any Prostate Cancer being Cured or a patient having positive results. So interest was lost--accept the idea never went away. It made sense to find a way to use treated or retrained T cells to do the job of eliminating cancer cells.
GOOD NEWS--->There are now new technologies that target multiple molecules on the cancer cell surface. I believe what I am hearing is that up to 4 targets are now being attacked. This would allow CAR-T[Modified T Cells] to still recognize the cancer even if that cancer sheds a target from its surface, to avoid extinction.
CAR-T Cell Therapy is a living drug[that is why the term *Chimeric is used]. And can persist in the body a long time and be able to recognize cancer years later and attack-->like a Real Vaccine attacks Bacteria or Viruses. My MO who heads Cancer R&D at Levine Cancer Institute--about came unglued last March when he told me he was getting the first patient in one of the new CAR-T formats. All he would tell me was crickets!
OUTLOOK FOR US: There are new CAR-T trials opening up---just last week we got one of our HU Members into a Dana Farber CAR-T Trial. I highly suggest for those that are looking at Lu-177 they may wish to look at CAR-T Trials as well. The intention when CAR-T started years ago was to replace Chemo. Maybe with the new technology, it can happen. I am Really High on this--not much is being printed, because it is all so propriety, and the researchers are dealing with N=x--where x is a small number--those being treated are in small clinical settings. And they are still collecting data.