My trial update 12 weeks in - Positiv... - Advanced Prostate...

Advanced Prostate Cancer

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My trial update 12 weeks in - Positive results

HopingForTheBest1 profile image

After Actinium225 infusion on day 1 + Keytruda infusions every 6 weeks (3 so far) + daily Enzalutamide, had updated blood work and scans at week 12. Bone and CT scans showed stability. Ga68 PSMA scan provided much clearer picture and results. Although PSA went up, previously identified lesions have shrunk. CTC count has dropped from 74 to 31. Good signs, to say the least. Continuing on the trial.

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HopingForTheBest1
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29 Replies
SeosamhM profile image
SeosamhM

Let's make it a merry holiday season for you, Hoping!

HopingForTheBest1 profile image
HopingForTheBest1 in reply to SeosamhM

Absolutely. 😄👍

Tall_Allen profile image
Tall_Allen

Good news! We all like it when lesions shrink!

Vitaminlover profile image
Vitaminlover

Excellent news! Thank you for sharing.

lewicki profile image
lewicki

sounds great. What was the amount of the Actinium ?

HopingForTheBest1 profile image
HopingForTheBest1 in reply to lewicki

90 Kbq/kg.

Faith1111 profile image
Faith1111

Thank you for updating. I’m always interested to see how you are doing. It sounds like this is really working well for you. Keep up the good work!

London441 profile image
London441

Great news!

Aodh profile image
Aodh

Delighted to hear your good news

Hugh

Concerned-wife profile image
Concerned-wife

Great news! Have been wondering how you were doing so thanks for sharing.

wagscure259 profile image
wagscure259

Glad to hear. Surely something to be thankful for. Here’s for continued lesion shrinkage!

Newyork6264 profile image
Newyork6264

Good news. Congrats and good luck,

TFBUNDY profile image
TFBUNDY

Shrinking is good. Usually....

Curehunter profile image
Curehunter

Congratulations on the good results. How much keytruda are you getting and how high did the PSA go.

HopingForTheBest1 profile image
HopingForTheBest1 in reply to Curehunter

400 mg. of keytruda. PSA started out at 35 at beginning of trial, down to 19, up to 27 currently.

Lowbed profile image
Lowbed

Great news! Thanks for the update.

Yank66 profile image
Yank66

Good news! And hope for the rest of us.

timotur profile image
timotur

Very positive news! Hope more to come-- best to you!

jfoesq profile image
jfoesq

Good news. And, thx for participating in a trial that may benefit all of us.

j-o-h-n profile image
j-o-h-n

Of course I'm hoping for the best for you. I am a great believer in Keytruda.... worked so far on my lung melanoma....I thing it's time for you to be Hopping for the best since it's working for you.....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 11/18/2021 7:52 PM EST

TylexGP profile image
TylexGP

Congratulations! Hoping for continued good progress.

Fanger1 profile image
Fanger1

That's wonderful news! What CTC test are you using and how is the enumeration given? It's more favorable to have less than 5 CTCs per 7.5 mL blood. With Biocept's test they usually report CTCs per 36 or 40 mL blood. Best wishes for continued success🙏

HopingForTheBest1 profile image
HopingForTheBest1 in reply to Fanger1

I do understand that less than 5 is a favorable number. But I still have cancer and expect I may never get to less than 5. With the # declining things are going in the right direction.

Fanger1 profile image
Fanger1 in reply to HopingForTheBest1

You got that right! Very few MOs seem to use CTC data so that's terrific you have this as a biomarker and it shows your counts have been cut in half. I've had both Cell Search and Biocept CTC testing. The latter can find both Cytokeratin Positive (CK+) and Cytokeratin Negative (CK-) CTCs, whereas Cell Search finds only CK+ and only looks at cell count (enumeration). The interesting thing is all the additional information scientists can learn from the CTCs that are found, for example, Androgen Receptor and it's splice gene varient, AR-V7. Hoping for the best right there with you🤞

julyturqsee profile image
julyturqsee

following your progress with this trial, and relieved it's going well after a difficult start. Here's wishing you further good news on dealing headon with the cancer.

HopingForTheBest1 profile image
HopingForTheBest1 in reply to julyturqsee

I hope my journey will encourage fellow warriors to seriously consider participating in clinical trials.

MateoBeach profile image
MateoBeach

Glad to hear of the positive response for you. Feeling OK? Happy holiday season and the best for 2022.

I guess I am having more age related issues than cancer, including arthritis, aches and pains, and difficulty walking. Starting PT soon to work on my legs. Also ramping up Gabapentin to 3 100 mg capsules daily.

Boywonder56 profile image
Boywonder56

I was lucky to get in titan trial at dx...ithas bought me atleast 2yrs over original death sentence...guess were still on deathrow....but not dead man walking.....im not that downbeat just words...

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