Duke CHAMP clinical Trial Update - Advanced Prostate...

Advanced Prostate Cancer

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Duke CHAMP clinical Trial Update

HerbieP profile image
16 Replies

Just an update for you fellow warriors. I've had my first infusion of the two chemos cabazitaxel and carboplatin and two immuno-therapies (nivolumab and ipilimumab) 14 days ago. My side effects have been less than what docetaxel were. A surprising side effect is I woke up to an erection (a surprise since I donated my boys to the hazmat bin couple year ago). I feel fine after the first few days and my brain fog seems less (or I'm getting used to it). Wife and I went boogie boarding on the coast last weekend and had a ball.

Only worrying thing is my ALT and AST are elevated in the high range, my care team expected it but are watching it closely.

Oh yeah, I got my third Moderna shot last Saturday as well, hopefully I will be as protected as the normals now (but still masking always). The photo is me in my car after the shot, happy as a clam (whatever that means).

16 Replies
6357axbz profile image
6357axbz

Sounds like an awesome program. All the best and please keep us posted.

Tall_Allen profile image
Tall_Allen

Great clinical trial! Those two powerful immunotherapies should give you some protection too. Liver enzymes often come back down with time.

addicted2cycling profile image
addicted2cycling in reply to Tall_Allen

HerbieP --- 👍👍 for continued enjoyable QoL and hoping the (A) numbers come down.

Tall_Allen wrote -- " ... Those two powerful immunotherapies should give you some protection too.... "

T_A --- Having received my 3rd Moderna this morning from what you mentioned above might I also have a complimentary level of protection thanks to the combo injection of Keytruda + Opdivo + Yervoy I received in 2015 or would any possible boost be aged out ???

TIA 🙂

Tall_Allen profile image
Tall_Allen in reply to addicted2cycling

I don't know how long it lasts. It's a good question for whomever did the trial - can checkpoint blockade lasts 5 years without boosting?

addicted2cycling profile image
addicted2cycling in reply to Tall_Allen

👍 Thank you

greatjohn profile image
greatjohn

Great pic and great news it seems.🥳

keepinon profile image
keepinon

Great Picture. You look like you have a great attitude which is so important for you and the people around you. Best of luck with the trial!!

Danielgreer profile image
Danielgreer

Hi Herbie, I wish you the best of luck! Did you have another treatment for NEC before the CHAMP trial? I was just diagnosed with NEC and my MO is recommending Carboplatin + etoposide.

HerbieP profile image
HerbieP in reply to Danielgreer

Hi @Danielgreer, I'd just finished 7 courses of docetaxel when they did another prostate biopsy and found out I was NEC. First thing they offered was the CHAMP trial, I did a bit of research and embraced it with open arms. I would have embraced anything that has promise of slowing down this beast.

Danielgreer profile image
Danielgreer in reply to HerbieP

I’m guessing that your caregivers may have suggested Docetaxel with carboplatin if you hadn’t already done the 7 courses without carboplatin? The alternative to carbo + etoposide that my MO is suggesting is Docetaxel + carbo which I may do. I haven’t done Docetaxel yet so hopefully that will help. Otherwise I may try to join you in the CHAMP trial. Please keep us updated on your journey - thanks!

lewicki profile image
lewicki

Hi Herbie, do you have the trial number handy?Thanks

HerbieP profile image
HerbieP in reply to lewicki

clinicaltrials.gov/ct2/show...

lewicki profile image
lewicki in reply to HerbieP

Thank you.

tallguy2 profile image
tallguy2

Wow, so few side effects for all those drugs! You are an inspiration for us all. Keep up the fight!

tceinvestments profile image
tceinvestments

Great News....

Cooolone profile image
Cooolone

Wow, hope it all goes well for you!

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