PSA quickly rising while waiting for trial to start

[HopingForTheBest1]

Trial will finally start next week, while having anxiously waiting for what seems like forever. In the meantime my PSA has more than doubled to 37 in the past month. It was undetectable up until a few months while on Olaparib when it ran it's course after 2 years. Doctor's have been saying PSA is just one criteria. ☹️😠🤬

Having Ga68 PSMA scan today as part of the trial. Will start trial with a triple therapy of 225Ac-J591 + Keytruda + Xtandi all on day one. Going forward I will continue with daily 160mg dosage of Xtandi and 6 week infusions of Keytruda, with weekly blood work for the next 6 weeks.

Hoping for the best!

[Philly13]

Good luck!

[6357axbz]

Wishing the best for you. Keep us informed of trial results. By the way, what trial is it? Where are you having it done?

[HopingForTheBest1 in reply to 6357axbz]

At Weill Cornell and Dr Tagawa. NCT04946370

[6357axbz in reply to HopingForTheBest1]

Thanks

[dorke]

Hoping for the best for you 🤞

[Tall_Allen]

Let us know how it works. It's a great combo. I'm particularly eager to know whether the J591 ligand mitigates the salivary gland side effects.

[HopingForTheBest1 in reply to Tall_Allen]

That's definitely the expectation.

[Lowbed]

Good luck! I just finished AC 225 J591 trial- got 7 months out of it before PSA went up. Had 2 infusions in February.

[HopingForTheBest1 in reply to Lowbed]

Was it in combination with another drug?

[Lowbed in reply to HopingForTheBest1]

HiI had 2 infusions 2 weeks apart of just AC225 and J591. Your trial with the other drugs seems very interesting!

[HopingForTheBest1 in reply to Lowbed]

Hoping for nice results.😀👍

[Peterd110 in reply to Lowbed]

You just had 1 dose of each drug?

[HopingForTheBest1 in reply to Peterd110]

One dose of Actinium + daily Xtandi + Keytruda infusion every six weeks.

[Hidden]

Your PCa cells are going to have a no good horrible bad day….. Thanks for sharing your experience and I hope the treatment is wildly successful with few side effects.

[HopingForTheBest1 in reply to Hidden]

😀

👍

[BRCA2MX]

Looks like a fine trial. You're really running the obstacle course well.

Good on you! --from a BRCA brother

[treedown]

Wishing for the best outcome for you.

[GoBucks]

Wishing you the best, And thank you for participating and helping others in the future.

[Howard53545]

Good luck

[TFBUNDY]

Looks like a great trial. I hope the sledgehammer cracks all the nuts... Good luck

[Jackpine]

Awesome please keep us posted !

[Ahk1]

I wish you LOTS of luck. Praying for you.

[Hidden]

Dam ! I admire your steadfastness and I see no fear in you .. 🙏

[Faith1111]

Very interesting trial. We will all be waiting to see how you do. This forum is wonderful for everyone sharing information. One persons experience can impact many others. Let’s hope for a great success!

[NOCanceros]

I hope the best for you.George

[HopingForTheBest1 in reply to NOCanceros]

Who is George? Not me. 😀