What's next on tap

[Costarica1961]

Well the 12th cycle of carboplatin and cabataxal is on May 20th, this treatment regime has been successful bringing my Psa down from 243 to 6. Although I have been told 12 cycles are on the far end of what should be taken, so far I have been tolerating it pretty well, aside from burning pain with urination,some blood and added fatigue, in addition some other minor issues. I understand LU177 may be FDA approved this summer. I realize radium 223 is still on the table, although two onc docs said thats used as a last resort and does nothing to bring or keep your Psa down. My oncologist stated a while back there may be another chemo option but she didn't specify which kind. Any ideas or suggestions.

[Costarica1961]

Yes, it didn't work although got 18 mos out of zytiga

[Tall_Allen]

Wow! Great response to the chemo!

Remember, you are not trying to bring your PSA down, you are trying to reduce your cancer. You may want to discuss these options with your oncologist:

prostatecancer.news/2021/02...

With other cancers, when carboplatin+cabazitaxel worked, so did PARP inhibitors. You may wish to investigate one of the clinical trials for Xofigo + a PARP inhibitor, particularly if you have a DNA damage repair defect.

[Costarica1961 in reply to Tall_Allen]

Ok thankyou , how do you determine if I have a DNA damage repair defect. Radium 223 seems to be a viable next option, as well I am looking into more clinical trials. Is there any merit to my onc stating radium 223 is a last resort. Thankyou in advance.

[Tall_Allen in reply to Costarica1961]

I don't believe in saving anything for a "last resort." Therapies are almost always better if used earlier.

DNA damage repair defect is part of any genomics study you may have had.

[Costarica1961 in reply to Tall_Allen]

Very valuable info thankyou.

[HopingForTheBest1]

Genetic testing can help determine viable treatment options for you. Definitely discuss with your doctor.

[Costarica1961 in reply to HopingForTheBest1]

I have been tested a couple years ago it did not reveal much. And for some reason the pain meds didn't work at all during the procedure, it was 45 minutes of agony. Since then they wanted to do another one. I don't think so. Thanks for the suggestion

[Spyder54]

My Genetic testing was a somple blood draw alongside my PSA/Testosterone monthly draw. Were you talking about a bone marrow extraction?

[Costarica1961 in reply to Spyder54]

Yes, they dug into my bone with a sharp instument, never again.

[j-o-h-n in reply to Costarica1961]

As the saying goes "You were better off being poked in your eye with a stick"..... Geezamacripe, what shit we have to endure............Fight On Costa Rica....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 05/11/2021 6:08 PM DST