Has anyone had success re-starting me... - Advanced Prostate...

Advanced Prostate Cancer

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Has anyone had success re-starting medicine after Chemo?

FinalBossMatt profile image
24 Replies

I was thinking unless I am mistaken, people have said after Chemo, certain medicines work much better since

I mentioned in a previous post, Xtandi stopped working after probably two months and since it shot up so high (about 1.9 points a day after doing the math) Doc wants me to start Chemo. He just needs to get a biopsy on my hip since I thought it was sciatica.

My last 3 medicines that have failed are

1) Casodex (2 months)

2) Zytiga (I think 4 months, but kept taking it to be safe since I moved back to America)

3) Xtandi (5 months but probably lasted for two since I see Doc every 3 months)

One of my first thoughts is since Casodex maybe lasted a month or two, try to restart it along with the Lupron shots as well.

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FinalBossMatt
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24 Replies
Tall_Allen profile image
Tall_Allen

Whatever you do, don't go back to Casodex. The cancer learns how to feed on it, using it as a way to reactivate the androgen receptor. You never stopped taking the Lupron shots, I hope.

FinalBossMatt profile image
FinalBossMatt in reply to Tall_Allen

Nope. My doctor is pretty aggressive with wanting to kick cancers ass. He said I will always be on it.

flyguy profile image
flyguy in reply to Tall_Allen

I've failed Zytiga and then Keytruda & Xtanti while continuing Lupron. You suggest that Casodex not reccomended because cancer learns to feed on it. Any other alternatives to Caodex? I used Casodex about 6 years ago.

Tall_Allen profile image
Tall_Allen in reply to flyguy

Try alternating chemo and Xtandi. Sometimes chemo can re-set sensitivity to Xtandi.

Rechallenge with Zytiga and Dexamethasone if you haven't used Dexamethasone with Zytiga yet. Decent success rate.

FinalBossMatt profile image
FinalBossMatt in reply to

Never took Dexamethasone. I lived in Thailand and their medicine was obviously limited with my running success rate with medicines. haha

EdBar profile image
EdBar

Sometimes you can rechallenge Xtandi after a course of Jevtana, this has been effective in some guys as a way to get more mileage out Xtandi after they have become resistant to it. It is one of the possible scenarios that Dr. Sartor discussed with me for when that time comes.

Ed

cesces profile image
cesces

"My doctor is pretty aggressive with wanting to kick cancers ass."

There is statistical research that supports this approach to any adaptive infection or infestation.

Small restrained responses to prostate cancer, or to Covid pandemics, or to similar, just make things worse.

For example.

Weak waffling response in USA, UK, Brazil and India made things worse

Strong resolute response in China, Taiwan, Korea, Japan, New Zealand, and Australia snuffed it out quickly, and kept it snuffed out.

Same thing for prostate cancer. That is why we are seeing more research that skips sequencing and emphasizes chemo cocktails.

It is statistically smart to hit it hard early with everything in order to make it statistically difficult for it to develop adaptions.

GeorgeGlass profile image
GeorgeGlass in reply to cesces

Your covid claims are totally baseless and wrong, Plus, more people will die in the long run, by the draconion shutdown techniques used by many countries. The countries that are generally in good health, with low obesity rates, low diabetes, low heart disease rates all did very well against covid, because their bodies were not already diseased, and thus, they were able to fight off covid without much effort. Most of farica and Asia and Scandnavia eat mostly healthy foods from nature. They did very well during covid. Countries like Sweden did very well. Plus, tens of millions will die from the unhealthy actions they took during lockdowns. They disease train will continue to manifest itself for decades to come. Removing covid deaths from the equation, and the average mortality rates in America were significantly higher from other causes of disease, and that doesn't even factor in the damage from experimental mrna vaccines. The numbers, JUST IN the USA- 300,000 killed by the cv-19 vaccines; 2+ million handicapped, 13 million severely damaged. America faired so poorly because we have the most unhealthy diet in the entire world. It's mostly processed sugar and refined oil-based foods, and even the meats and plants are loaded with pesticides, antibiotics and stressful, toxic created animal products, which make people very vunlerable to any kind of respiratory disease. Locking people down, and keeping them away from nature and social activity makes their immune system even weaker. Plus, America did not embrace or disseminate alternative types of vitamins and nayural treatments, which were proven to significantly reduce death from covid. These alternative treatments lowered inflamation and kept the lungs from honeycombing, which made it impossible for people to breath. Almost everyone who was told to lay in bed, get on a ventilator, or take remdesivir after being in the hospital, had very high death rates. Those people who took preventative measures in accordance with the FLCCC protocol, had very low death rates.

cesanon profile image
cesanon in reply to GeorgeGlass

You lost me at the first sentence: "Your covid claims are totally baseless and wrong, "

Then followed by Q*non/m*ga talk: "draconion ", "They disease train", "JUST IN the USA- 300,000 killed by the cv-19 vaccines; 2+ million handicapped, 13 million severely damaged", " Plus, America did not embrace or disseminate alternative types of vitamins and nayural treatments, which were proven to significantly reduce death from covid. "

LOL source please. Faux News maybe? Yeah, dump the masks and self-medicate with info war vitamins. Why not. LOL

But yeah sure, this is a complicated subject. It doesn't help when it gets politicized.

It is the politicization that kills people.

Because it fogs up with windshield for the scientists that should be driving health policy.

Look no further than pols in Florida telling the Docs how they can and can't handle a pandemic.

Even this small attempt to politicize what should be an objective discussion will kill people when we next run into the next haemorrhagic fever (and it is coming) that spreads quickly... not like Covid but perhaps like the common cold.

Will this small rant cause millions of deaths. Nah. Will it contribute to a few of many millions. Maybe not even that. Will the next 10-20 years of your personal rantings over the remainder of your probable life expectancy on this subject kill a few. I suspect so.

Thanks a lot for your past and future expected contributions to the QOL of others, some yet to even be born.

"Those people who took preventative measures in accordance with the FLCCC protocol, had very low death rates." I followed FLCCC protocol myself until I determined there was no credible supporting evidence. I even talked with the Doc that formulated him. I begged him to do some respectable research to prove it to the doubters. He said he was doing it in Canada. He never did. He never did! That was all he had to do.

So if you catch yourself spouting simple answers to complex problems... maybe you should stop and reconsider whether or not you fully understand the problem.

See Dunning Kruger effect:

thedecisionlab.com/biases/d...

Thank you in advance for your thoughtful and considered response to this posting.

jfoesq profile image
jfoesq

Matt- others should be able to answer your question better than me. All I wanted to say is that I have been on Lupron for 8+ years with Zytiga for amajority of those 8 years. I am curious whether you doc thinks Lupron may be worth trying?Best

Jeremy

FinalBossMatt profile image
FinalBossMatt in reply to jfoesq

I already said I was on Lupron man. :)

jfoesq profile image
jfoesq in reply to FinalBossMatt

Apologies- I must've missed that.

FinalBossMatt profile image
FinalBossMatt in reply to jfoesq

It happens. :)

Just hoping the chemo can kill off enough of the dormant cancer cells to where Lupron + said medicine = cancer ass kickery.

jfoesq profile image
jfoesq in reply to FinalBossMatt

Me too

squidlicious profile image
squidlicious

I similarly failed Xtandi and Zytiga while on Lupron. Then failed chemo. But I’ve been undetectable for 27 months with Lupron plus Erleada.

FinalBossMatt profile image
FinalBossMatt in reply to squidlicious

I could do 27 months. :)

GeorgeGlass profile image
GeorgeGlass in reply to squidlicious

that's remarkable. Goes to show that they are not all the same.

monte1111 profile image
monte1111

No answers from me. I hope chemo works well. I had 8 cycles (to begin with) and that and lupron started me on a downward path. Hip biopsy doesn't sound like a lot of fun. Other meds out there, best of wishes.

GeorgeGlass profile image
GeorgeGlass in reply to monte1111

Monte, you mean that chemo was your initial treatment? Can you expand on the downward path you mentioned? I'm sorry to hear that.

George

monte1111 profile image
monte1111 in reply to GeorgeGlass

Downward path was a poor choice of words. Thanks for your concern. Chemo, Lupron and Xtandi have kept me on a stable path for 6 years now. ("extensive, innumerable bone metastasis"). Don't know why it hasn't spread already (liver, lungs, etc.) PSA test next week. I've been 0.2 for a long time. Maybe because I'm always waiting for j-o-h-n's next lame joke. I should send him some crutches.

FinalBossMatt profile image
FinalBossMatt

All these answers are great and still helpful because I like seeing people do good.

It also makes me laugh thinking about how so many goofs say, "Hey man, all you need to do is drink your pee, give yourself a coffee enema, eat a non-existent vitamin that digests as cyanide, and juice fruits and veggies while getting rid of all the useful pulp that has all of the nutrients in it, and you'll cure yourself of cancer... it's just that easy."

Apparently, it's not hahaha.

j-o-h-n profile image
j-o-h-n in reply to FinalBossMatt

and don't forget the goof about Chocolate chip ice cream (two scoops)...

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 05/03/2021 7:47 PM DST

in reply to FinalBossMatt

"Hey man, all you need to do is drink your pee, give yourself a coffee enema, eat a non-existent vitamin that digests as cyanide, and juice fruits and veggies while getting rid of all the useful pulp that has all of the nutrients in it, and you'll cure yourself of cancer... it's just that easy."

Most of the people who push this nonsense either have stable disease in long-term remission (IE. local prostate cancer treatment with no reccurance) or they don't have cancer at all. They use their good luck as a soap box from which to preach at those of us with aggressive, advanced disease who will die quickly without proven treatments.

Another thing we see is people advocating for all these unproven alternatives while also using conventional treatments (that of course are doing nothing but creating awful side effects). Many times the treatments that are actually working are conveniently not even mentioned. I've seen plenty of this kind of thing on the forum.

We just have to ignore the BS that they present.

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