Orgovyx (relugolix) is "now available through authorized specialty distributors."

[Tall_Allen]

investors.myovant.com/news-...

I don't know who the distributors are or which drug plans already cover it.

[Hidden]

I've been looking forward to this. I don't need to do this yet. But someday I might need to go low T again (my MO disagrees).

[Hidden]

I already did a drug price lookup on CVS Caremark through my employer's drug plan:Cost is $1800 per 90 days supply (120 Tablets per month) which is cheaper than what Eligard currently is for me ($5600/3 mo) from the hospital..

[Tall_Allen in reply to Hidden]

That's very reasonable.

[JPnSD in reply to Hidden]

Similar to 3 months of Firmagon if I were able to get similar pricing for 90 days of tablets.

[Hidden in reply to JPnSD]

Personal decision but I think I would still get the Eligard shot since I'm doing very well on it with little to no side-effects. I don't need more pills to remember to take and order.

[JPnSD in reply to Hidden]

No side effects would be nice. Since I am doing hot flashes, weight gain and lethargy already with Firmagon...nothing to lose

[Tall_Allen in reply to JPnSD]

I expect the same side effects as Firmagon.

[6357axbz in reply to Hidden]

I hear you!

[rust in reply to Hidden]

Holy gynecomastia Batman!

[Hidden in reply to rust]

KAPOW!! BLAP!! BAM!!

[dhccpa in reply to Hidden]

All we have to do is hope and pray that an insurance carrier is as logical as a regular human.

[Tall_Allen in reply to dhccpa]

LOL. I think the sky is a different color on their planet.

[Bodysculpture]

Thanks again Tall Allen

[JPnSD]

Any cons to switching to this drug from monthly Firmagon injections?

[Tall_Allen in reply to JPnSD]

The risk of the long-term unknowns.

[JPnSD in reply to Tall_Allen]

Thanks. Understood. Well, how else will we get such data :). Guess I would have to weigh injection pain with daily pill use....and hope for the best. I am awaiting pricing from my healthcare provider.

[dhccpa in reply to Tall_Allen]

Is there any advantage to alternating the various hormonal treatments? Like less cancer resistance development to any one of them?

[Hidden in reply to dhccpa]

Is it resistance to the drug or is it resistance to castrate levels of T? I believe its the latter and not the former. Remember. All CR means is that the pca can thrive in very low-t environment.

[dhccpa in reply to Hidden]

I wasn't sure. That's why I ask the experts.

[Hidden in reply to dhccpa]

It's Firmagon in a pill.

[Cooolone]

The biggest difference I found while reading through some study literature was with the pill form, patients will experience a quicker rise to efficacy of the drug lowering testosterone (2-3 days vs weeks for Lupron) and the level maintain it's T suppression at a constant as opposed to the curve of injectable anti-androgens.

This curve IMO is problematic as it will allow the PCa to breathe so to say as the injectable anti-androgens lose their efficacy while the drug diminishes in our bloodstream, of course until the next dose and it rises again. With the pills, and as long as they're taken religiously, will maintain a constant level of the drug. As noted, nobody really knows the long term prospectus on this, and SE's have been noted as the same other than less effect upon those with cardiac issues.

I've discussed with my MO and look to switch. Of course we shall see what my insurance carriers take on it will be. But I would argue that for advanced patients, there is benefit over some of the injectables for the reasons I've stated above. I was watching and waiting for the FDA approval thru late 2020... Glad it happened!

[Tall_Allen in reply to Cooolone]

Firmagon acts equally quickly and maintains a steady-state concentration in the blood. It does cause injection site reactions and requires monthly shots. The downside of any new medication is we lack long-term data.

[Pop_Meme]

My husband has been prescribed Orgovyx and Zytiga. We were able to get Zytiga through Optum RX, but it's been a little more complicated to get Orgovyx. Optum RX doesn't supply it, so prescription has now been sent to US Biotech Services (I think that's the name). Hopefully we hear from them soon.