Zytiga failed, trying chemo+Rubraca

[COOP8]

Has anyone tried Zytiga with no response, and did you find any other treatments that worked? Any experience with Rubraca?

My husband finished chemo a year ago (Docetaxel plus carbo platin). Lowest PSA was last Oct/2019 at 3 (down from 588 in Jan 2019).

Jan 2020 PSA started rising to 7, then 11, then 25. Started Zytiga in April and PSA continued up to 100, then 105, and now at 250 12 weeks in. We’re switching to a clinical trial and he’ll start chemo again next week for 4 treatments followed by Rubraca (Recuparib). Has BRCA2, mets in bones.

[GP24]

There is a certain percentage of patients where Zytiga does not start to work.

I would skip the next chemo and just try Recuparib first. He has got enough chemos for now.

[Tall_Allen]

Sounds like a great plan! I've heard really good reports of the MD Anderson trial of Jevtana+Carboplatin followed by PARP inhibitor maintenance, especially in guys who are BRCA2+. There seems to be a synergy in using those therapies together, and based on his great response to chemo the first time, there's every reason to believe it will work again.

[HopingForTheBest1]

Was on Zytiga for 6 months. Also BRCA2+. Continued on ADT and switched to Olaparib. Have not had chemo. PSA has been undetectable so far for over a year. PARPs work for BRCA mutations. Rubraca is used for patients who have had chemo. Was recently FDA approved, as was Olaparib.

[oilcan4]

My husband was diagnosed with Stage 4 prostrate cancer with bone metastasis in April 2019. I believe his PSA was 12. He received his hormone shot and put on Zytiga. His PSA went to 15 and then to 24 after about 6 months. He was then put on Xtandi but PSA never went down and slight increased after 6 months with increasing bone mets. They now have recommended chemo which starts this month. He is to get a infusion to strengthen his bones and has had spot radiation. He has continued receiving his hormone injections. Hoping chemo will go well as is on tramadol and extended release morphine for bone pain. His PSA is now 60.

[j-o-h-n in reply to oilcan4]

It can?

So I've notice that it would be helpful if you would provide us with your husband's bio info: Age? Location? His treatment scores psa/gleason? His treatment center(s)? Doctor(s) name(s)? Thank you!!!

All info is voluntary but it helps us help him and helps us too. If you do reply you may want to add that info to your home page for your and members reference purposes....

Good Luck, Good Health and Good humor.

j-o-h-n Thursday 07/16/2020 6:31 PM DST

[j-o-h-n]

Greetings COOP8, Would you please be kind enough to let us know a little more about your dear husband. Age? Location? His treatment center(s)? Doctor(s) name(s)? Thank you!!! All info is voluntary but it helps us help him and helps us too. If you do reply you may want to add that info to your home page for your and members reference purposes....

Good Luck, Good Health and Good humor.

j-o-h-n Thursday 07/16/2020 6:27 PM DST

[COOP8 in reply to j-o-h-n]

My husband is 51, diagnosed at age 50. Treated at Seattle Cancer Care Alliance (associated w Fred Hutch research center and UW).

[j-o-h-n in reply to COOP8]

Thank you for you quick and detailed response. Well there have been many young men joining our group recently. The plus is that PCA is a slow growing disease and most men die with it rather than from it. There are many many new meds being offered to Pca customers (I don't like the word patients) every few months with good results. Make sure you and your husband take care of yourselves because you'll be around for at least 35 years. You both will be celebrating the year 2055...... Stay well and keep posting here. It's a great site.

Good Luck, Good Health and Good humor.

j-o-h-n Thursday 07/16/2020 7:02 PM DST

[treedown in reply to COOP8]

Who is your Dr? I had a second opinion down there with Dr K Lee. Unfortunately my insurance won't pay for treatment down there, but he agreed his treatment would have been no different than what I got.

[COOP8 in reply to treedown]

He sees Dr. Heather Cheng. She has a focus on genetics, and since my husband is young with aggressive BRCA2+ she is a good fit for us. We’ve been very happy with his care.

[treedown in reply to COOP8]

Sounds great that must be very comforting. I wish you both the best on this journey.

[immunity1]

Based on his BRCA status and recent chemo treatment history I would recommend going for the PARP inhibitors firstly. Also it means less likelihood of possible chemo side-effects such as peripheral neuropathy, which I am familiar with. R

[immunity1]

Zytiga didnt work with me either.R