Some success is being found treating those with COVID 19 by dosing them with 16X the recommended amount of vitamin C orally.
If vitamin C was intravenously infused in larger amounts over a span of time it might be even more effective than the "small" doses that are being given to the patients.
Links that work for me aren't working here when included in this post. Copy the below and type it in your search bar. Doing so should take you to the article in the New York Post. There are quite a few articles about this as it is creating some excitement.
I'm sorry! I tried several links without issue but once included in the post the links did not work, Not one of them!
Copy the wording between the lines in the post and put it in your search bar. That will take you to articles, by the NEW YORK POST and others, about the success doctors in NYC are finding that patients, given what are considered to be large, oral, doses of vitamin C are having.
The patients in NYC are getting the 1,500 mgs by IV, 3X to 4X daily. Per the article the recommended amounts of C to supplement with normally, or orally is 75 mg for women and 90 for men. If you didn't access the article that wouldn't have been clear.
New York hospitals treating coronavirus patients with vitamin C
By Lorena Mongelli and Bruce Golding
March 24, 2020
Dr. Andrew G. Weber who is a critical care specialist and pulmonologist with two of Long Island's Northwell Health's facilities says that he gives his intensive care patients 1,500 mgs intravenously immediately. You are right. I typed oral rather than small--now corrected.
Those of us who have had intravenous vitamin C infusions would consider 1,500 mg intravenously a small amount. A few infusions of smaller amounts building to a somewhat standard 50,000 mgs is normal.
Interesting that vitamin C levels in those with COVID 19 drop because the infection initiates sepsis.
At the end of the article it is said that a clinical trial about vitamin C's effectiveness in treating Coronavirus is being conducted. Results next fall.
Oral ascorbic acid (AA) ends up in the bloodstream after being ingested, just as IV C. To say they have opposite effects (Example: one depresses immunity while the other inhances?!?) makes no sense to me. I would need to see peer reviewed research on that statement, which is very broad and general.
Oral C in extreme doses can cause bowel intolerance which IV administration avoids.
Cells will uptake the AA from the bloodstream regardless if ingested or IV administered.
You are ignoring the fact that oral and iv administration are metabolized differently. In the concentrations achievable orally, ascorbic acid acts as an anti-oxidant. In the concentrations achievable iv, ascorbic acid is pro-oxidant.
Here's the research you wanted to see:
"1.2. Possible Mechanisms of Anti-Tumor Effects of Vitamin C
Several major mechanisms have been proposed to explain why only pharmacologic ascorbate concentrations have cytotoxic effects on some but not all cancer cells. Two mechanisms include increased pro-oxidant damage that is irreparable by tumor cells, and oxidation of ascorbate into dehydroascorbic acid (DHA), which is an unstable metabolite and can be cytotoxic [20]. Most data indicate that the first pathway predominates, specifically by generation of extracellular hydrogen peroxide (H2O2) by pharmacologic ascorbate and a trace transition metal, usually iron [29,30]. Hydrogen peroxide is cell permeant, and, in the presence of pharmacologic ascorbate, H2O2 reactive oxygen species (ROS) are formed extracellularly and/or intracellularly [31]. These ROS have multiple downstream targets, including but not limited to DNA damage, mitochondrial damage, and stimulation of apoptotic pathways [29,32,33]."
Yes, you are right in this case. Thank you for the information.
So, in concentrations only achievable through IV administration, Vitamin C acts as a pro-oxidant to some types of cancer but not other types. IV C usually shows little toxicity and few side effects if you have decent kidneys so it apparently is NOT pro-oxidant to normal body cells....If you have the right kind of cancer, seems like an avenue to investigate, unfortunately, the evidence doesn't seem to indicate an effect on PC.
My take is IV Vit C acts as a pro-oxidant to certain types of cancer cells under certain conditions.
Orally, ascorbic acid acts as an anti-oxidant. Our bodies limit the plasma concentrations achievable through oral administration. IV ascorbic acid can build up to much higher concentrations where it can exhibit pro-oxidant effects in cancer cells.
I read the reports. It also says that the patients are being treated with Chloroquine and Azithromycin and additionally Vit C. Difficult to separate the effect of all 3 like this. Proper clinical trials are needed. Since it is harmless in these doses I think this may be harmless even if not effective.
No. Take them as you normally would. Orally vitamin C acts as an anti-oxidant.
Vitamin C infused intravenously when taken in as food by cells forms hydrogen peroxide.
The article said that COVID 19 depletes the patient's bodies of vitamin C and then sepsis can occur. The vitamin C, although in small amounts in my opinion, 1,500 mgs given three to four times a day, returns the patient's C levels to a normal range.
Vitamin C infusions of, for example, 50,000 mgs over the course of either side of an hour expose cancer cells to the C. Vitamin C is so close molecularly to sugar that cancer cells mistake it for sugar and eat it. The C then destroys the cancer cell by oxidizing it. The patient's level of C is measured with diabetic test strips. The therapeutic range is above 400 I believe. Vitamin C when infused doesn't harm normal cells.
Interesting question! Lipsomal, like regular C, helps prevent oxidative stress which can lead to cancer. Lipsomal is supposed to be better assimilated, a unique delivery system, and thereby utilized better. Copy these into your search bar.
Bring it up and click on the blue "one study" to access a study posted by the National Center for Biotechnology Information--Look at the acknowledgement at the end. Credible people and organizations.
The below is interesting. I would want to see the vitamin C level measured to believe the claims that 6 grams of Lipsomal vitamin C is the equivalent of 50 grams by IV. A study--Lipsomal is supposed to avoid some of the unpleasant side effects of normal oral supps?
An addendum: Keep your doctors informed about what you are doing. I have friends that get vitamin C infusions and there is communication between their conventional docs, the doc who does the Ivs and the patient as to what supps they take and so on. It is a team effort.
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