Hey everyone,
I've been trying to find information about a chemo cocktail for advanced prostate cancer treatment and google hasn't been as helpful as I thought it would. I figured maybe this very informed and helpful community might have some information about Docetaxel and Carboplatin. When is it used, how are the side effects and so forth. Thanks so much!
It is given for undifferentiated prostate cancer or neuroendocrine. It has also been found to work in cases where a PARP inhibitor also works.. MD Anderson has a trial starting with the combo of Jevtana and carboplatin and transitioning to olaparib as a maintanence therapy. My friend's experience of the combo was that it made him very dehydrated - he had two saline infusions in the week following each chemo. He also had Neulasta and an antihistamine.
Do u have a sense of the timeline of the Pca developing resistance to the parp inhibitor?
Do u think there are any strategies to delaying such full resistance, say , cycling use or lowering PARP inhibitor dose, to avoid selective aggressive Pca cell survival?
Sorry, I don't. But it may be a really bad idea to use intermittently or at a lower dose, just as it's a really bad idea to do that with antibiotics - you might wind up causing the resistance you're hoping to delay.
Thanks
I recently went through Cabazitaxel (kind of new version of Docetaxel) and Carboplatin combo. It's all right, but yes dried my skin, threw up a few times at the end cycle, felt nauseous and tired. You do need white blood cells stimulation (Neulasta). I'm recovering now and blood counts are coming up. My only remaining noticeable effect are weird hair: it used to be thick and curly even after the first chemo, but now just straight, sparse and thin. Also, the stomach can't take certain foods: converts them straight to water and gas 
My husband had this combination after liver Mets were detected.
He did alright- but unfortunately got a raging infection in his port. Hospitalized month of September last year and chemo discontinued.
It was hard to get the infection under control.
He was never able to receive more chemo.
He did have Neulasta.
I have had this chemo combo for 18 infusions, with #19 on Tuesday.
For me, I have mets in lymph nodes since diagnosis in August 2012 and mets in liver discovered in September 2017. Immediately began chemo in September 2017, and so far have had 2 rounds of 6 cycles each and 2 rounds of 4 cycles each. For me, this chemo combo is still working.
We used Xtandi as a rechallenge after rounds 1 and 2 and then have been taking Xtandi continuously with chemo rounds 3 and 4.
Best Wishes. Never Give In.
Mark, Atlanta
Hi, our story here. My husband Barry (diagnosed last August) had 5 cycles of docetaxel as a first-line treatment when his stage 4 pc was considered still castrate sensitive. He also had Lupron. He had almost no side effects, which was a relief. I know others don't have it so easy. We placed ice chips around his hands and feet during his chemo treatments, as I read it can prevent neuropathy, a common side effect, and he never got neuropathy. Although his medical oncologist wasn't familiar with this, he was fine with it. Barry's PSA went down, and then went up; after it was still rising three weeks after Cycle 5, his oncologist changed his medication to Xtandi and the PSA already has started to go down. As far as the "cocktail" is concerned, if the Xtandi didn't work, the oncologist planned to try Jetvana (caboxytaxel) by itself, and if that didn't work, he was going to add carboplatin to it. Docetaxel together with carboplatin was never discussed. If the Xtandi stops working, the oncologist also plans to get another biopsy and have genetic testing (probably Foundation One). I hope this helps. I hope for the best for you....
I am doing cycle 15 of this cocktail tomorrow. It’s been very effective for me of three different batches. It removes pain and has slowed down progression. There are many documented side effects but none are crippling. I still go to work. Many go away after the first week although I will say after this many cycles the anemia is nasty and clearly it’s not doing my skin any favors.
I had 6 rounds of Docitaxel. Tolerated fairly well, but got the familiar hair loss, weight loss and fatigue. Recovered well afterwards to the point where 6 months after last session, I went on a 33 day 800 Km hike across Spain. The one thing I would advise people is to get the frozen mitts for your hands and if possible, feet. This will minimise neuropathy. I had frozen mitts for my hands (didn’t want to lose ability to play guitar) and they worked very well. The difference between neuropathy of hands vs feet is very noticable.
Would you be kind enough to give us more information about your Dad... Age, Location, Scores psa and gleason, location of treatment center(s), treatments to date, doctor's name(s)? Thank you.... All info is voluntary but it helps us help you and us too.
Good Luck, Good Health and Good Humor.
j-o-h-n Sunday 03/15/2020 10:12 PM DST
Hi John,
My dad is 76 years old, PSA .08, Gleason 9, treatment center is a local center here in the twin cities, we couldn't get in at the mayo. Treatments to date are 6 infusions of Docetaxel and firmagon shots. Oncologist is Dr Joseph Levin.
Hello Isteacke, Thank you for your reply. You may want to cut and paste your Dad's info on your hope page under your userID. This way you can easily share it with other members without having to type it over again. Why couldn't your Dad get into Mayo? Make sure he gets to see a good oncologist who specializes in Pca... If you need a name(s) for a good one in the Mini apple area just post and ask here. Tell your Dad I wish him well and to keep smiling (you too).... BTW I'm in the Big apple.....
Good Luck, Good Health and Good Humor.
j-o-h-n Monday 03/16/2020 7:19 PM DST
I’m undergoing a cocktail of Cabazitaxel and carboplatin now. I was told the carboplatin is tough. Only 1 round so far. For me extreme fatigue, dehydration nausea vomiting and diarrhea. I receive hydration therapy with some added calories 2 times a week at the hospital because I get so dehydrated . My appetite got so depressed I did medical cannabis starting last Saturday for the first time. It seems to be helping. The first night I ate 3 steak enchiladas rice and beans plus a large serving of ice cream. I had lost 12 lbs in 2 weeks. I drink water like nuts but I’m still dehydrated. For me it’s been rough road.
Reaching the end of treatment, suggestions beyond Docetaxel and Carboplatin.
Carboplatin
Docetaxel
