According to a Swedish Study, that some of you have already read, overall survival was significantly increased. To start, yes I have already been vaccinated as of about 2 months ago. But I used a Live Virus, instead of the Dead Virus Dukoral. I will break the post into 3 sections--->Data from the study, vaccines available today, and a small summary.
!] The Swedish study ran from 2005 to 2014, that included 841 Pca patients, that were vaccinated with a Cholera Vaccine--that was not described--unless I missed the name. But was probably Dukoral. These patients were compared to @89,000 Pca patents not vaccinated. The net results, thru extrapolations, of the differences in those vaccinated and those not--> had indicated, a 43% decrease in Prostate Cancer Mortality, and an overall 47% decrease in Overall Mortality. The average time of vaccination, was 27 months after DX. And follow-up was 5 years. The average age for the vaccine use was 64 years old. The study indicated that there was a nice increase in NK[Killer Cells], and Macrophages, and an Increase in Anti-inflammatory responses. These are things we like to see.
2] So personally I tried though the Health Department to get vaccinated with a script from my Integrative Doctor. I was denied, as there is a rule you have to be 64 years old or younger, and with proof you are going to a country that reports Cholera, among the natives. I guess this is Senior Age Discrimination! NPfisherman ran down the vaccine in use and it is Dukoral today. Approved in Europe and Canada but not in the United States. A live Injectable Cholera Vaccine had been used for many decades, in the USA. So some men on this site are planning to go to Canada, or to buy on-line, from a pharmacy in Canada, that will mail to you.
This is where I got involved, and got a hold of A pharmacist I know in Windsor Canada. He warned about having the vaccine sent through the mail. As the shelf life is about 2 weeks which gets reduced if temperatures above room temperature occur. So mailing during summertime is out. At anytime Customs can hold up the mailing. So going in person, taking the first of 2 doses and having to take the 2nd dose to complete the vaccination at 7-10 days after the first dose is the procedure. I did not like the over-all procedure, and I personally preferred a Live Virus, even though there are reports that the Dead Virus is as effective and one poster thought superior. But this information is denied by the Manufacturer of a New Live Virus approved by the FDA in July of 2018--> called Vaxchora.
I found the Manufacturer, Vaxmax--they produce the Cholera vaccine---> Vaxchora in Bermuda. I spoke with a principle and then was put in contact with the V/P of R&D. We had a long conversation, and they were quite aware that their vaccine is being used for Pca. When pressed I was told that both the Live and Dead Vaccines will be as effective, except that in 2 years the amount of effectiveness of Dukoral is less than 50% and the Vaxchora, will be effective for 3 years, before needing a booster. Longer protections usually occur with live vaccines. I was satisfied with the technical exchange I had.
So how is this Vaccine obtained. First you need a Doctors Script specifically for Vaxchora. And it appears that Walgreens has an arrangement, based on their distributor, that also distributes the Vaxchora. The distributors name is [AM-Resource-Bergen]. When I went to Walgreens I had to tell them which distributor to use as they had never seen a script for it. Also the Vaxchora comes in frozen, like the new Shingles Live Virus, and is a single dose, where the Dukoral is a 2 dose procedure. Yes it is expensive--was 328 dollars and Medicare did not cover. It was less than the cost of Airfare to Detroit plus a rental car to go to Canada.
3] In closing besides the benefits of NK Killer Cells, Macrophages that eat up cells not compatible with the human body, and the Anti-inflammatory benefits, there are benefits in the possible destruction of mRNA strands/or the Vaccines may interfere with protein signaling for Pca cells which are needed for information to wake, or divide, and make daughter cells.
One re-purposed drug getting a lot of attention today is Niclosamide. The interference's that are postulated may be the key to the longer survival benefits. Both my MO's applauded when I told them that I added the Cholera vaccine. There is a lot of interest, which includes Ferroquine an anti-Malaria Drug that has been looked at in small studies, and a companion type drug to Niclosamide---->Nitazoxanide, another anti-worm drug, that went thru strong positive studies in Norway.
My intuitiveness, whatever it is worth, indicates to me that the earlier you can use these drugs, if it is your choice to do so, the better the outcome for OS. I see the benefits being most useful for those men that are PSA undetectable, or with low burden PSA/Disease. Niclosamide is being used for late stage disease, by some MO's. I would prefer to see earlier use.
Anyway you cut it and which Cholera Vaccine you might wish to use---the 43% overall survival is nothing to sneeze at. Remember the average time of use after DX was 27 months in the Swedish study. Hope the above helps considering a Cholera Vaccination.