Proton pump inhibitors and prostate cancer

[Ralph1966]

Proton pump inhibitors promote the growth of androgen-sensitive prostate cancer cells through ErbB2, ERK1/2, PI3K/Akt, GSK-3β signaling and inhibition of cellular prostatic acid phosphatase.

ncbi.nlm.nih.gov/pubmed/307...

[j-o-h-n]

Dr. Mugil Google says:

Proton pump inhibitors (PPIs), and how do they work (mechanism of action)?

Proton pump inhibitors (PPIs) reduce the production of acid by blocking the enzyme in the wall of the stomach that produces acid. Acid is necessary for the formation of most ulcers in the esophagus, stomach, and duodenum, and the reduction of acid with PPIs prevents ulcers and allows any ulcers that exist in the esophagus, stomach, and duodenum to heal.

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 10/30/2019 4:39 PM DST

[GeorgeGlass in reply to j-o-h-n]

Yes, but do they speed the growth of the prostate cancer?

[j-o-h-n in reply to GeorgeGlass]

Beats the shit outta me....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 10/31/2019 11:02 AM DST

[Gemlin_ in reply to GeorgeGlass]

Unknown, but for men with prostate cancer, those on PPI’s have a significantly higher rate of Gleason-7 (or higher) prostate cancer compared to men who do not take PPIs. Most people who take PPIs are typically older and less healthy is one possible reason.

[RealtorEmeritus]

My lord, that is scary news. I have been taking PPIs for 30+ years! It's the first pill I take when I get up in the morning. My oncologist said nothing about this. That is disturbing.

[Ralph1966 in reply to RealtorEmeritus]

Apparently Tagamet 200 mg twice daily is a good alternative. I was taking losartan since 2014 and had PCa 2017. The pharmaceutical company withdrawed that brand and change it to another brand, because of carcinogenesis they found. Nothing is conclusive here, may be tomorrow a new research say PPInhibitors help cancer patient live longer!

[GeorgeGlass in reply to RealtorEmeritus]

Ppis after really only supposed to be taken for a couple months. After that, they permanently change the way that the body processes food and the way it uses acid or lack thereof.