Department of Clinical Sciences, Lund University, Skåne University Hospital, S-20502Malmö, Sweden.
2
Ministry of Health and Family Welfare, Government of India, India.
3
Centre for Translational Microbiome Research, Department of Microbiology, Tumor and Cell biology, Karolinska Institute, SciLifeLab, SE- 171 76Stockholm (Solna), Sweden.
Abstract
There is an established link between birth parameters and risk of adult-onset cancers. The Developmental Origins of Health and Disease concept provides potential underlying mechanisms for such associations, including intrauterine exposure to endogenous hormones (androgens and estrogens), insulin-like growth factors, etc. However, there is conflicting evidence on the association between birth parameters and the cancer mortality risk. Therefore, we aimed to review and analyse the available data on the association linking birth weight and birth length with cancer mortality. Eleven studies were identified, published until April 2019. A significant association between birth weight and the prognosis of cancer (overall) was found (relative risk, RR 1.06, 95% confidence interval, CI: 1.01, 1.11), with low heterogeneity (I2 = 27.7%). In addition, higher birth weight was associated with poorer prognosis of prostate cancer (RR 1.21, 95% CI: 1.02, 1.44). However, the association of birth weight with breast cancer mortality risk in women was not significant (RR 1.16, 95% CI: 0.93, 1.44), which might be due to high statistical heterogeneity (I2 = 67.9%). Birth length was not associated with cancer mortality risk (RR 1.0, 95% CI: 0.90-1.11). It might be inferred that birth parameters are not associated with cancer mortality as strongly as with the risk of developing cancer. Also, the association between birth parameters and cancer mortality risk is not uniform and varies according to its subtypes, and study characteristics/design. This highlights the need for further prospective studies.
Hi P, Thanks for digging interesting stuff up. BUT but BUT I hope its not just me but my research in remediating and avoiding health problems has a larger influence then these "predispositions". Factors like diet, nutrical, medicinal protocols that over ride most of these pre-disposition factors.
My studies of health in general finds on average first born are much healthier (stollen a good deal of mothers nutrician) then last born and etc. Back to back babies are hard on the mothers body. History was by 4th child mother was loosing teeth due to bone loss.
Then diet choices that lead to high BMI leads to ... many many factors.
So to swing the pendulum back to being hopeful, vs hopeless that we are pre-destined from pre-birth to bla bla, its my believe that we can completely negate such factors and have great out comes. Even improve a currently poor health situation by making changes. I hope we all agree?
IE quit smoking, dump the scienceless advice of low fat diet and eat paeleo (or similar), loose weight, drop insuline/blood sugar, etc etc.
BTW a very good documentary came out in 2019: called "Fat". Google, its on amazon Prime. Also another very good Movie/documentary called: Fasting, also 2019. Fantastic science and results.
Thanks again for interesting statistics and research! Just wanted to swing things back into our control and daily choices.
Story; a relative lived in a house half way up a lime stone cliff, twice houses near by where crushed by cleaving off bolders thankfully not killing anyone thankfully. My relative said; well I guess I can eat all the potatoe chips I want I'm going to die in my sleep anyway, right? NO! LOL they sold and moved and now live a very healthy lifestyle and seem likely to live till their natural life spans. They took action vs giving in to a fateful view of their future.
Being short has disadvantages in life, but short men have less PCa.
The PCa problem is assumed to be due to periods of sustained exposure to growth hormones.
The body does not commit to growth when the supply of nutrients is unreliable. The studies that look at green tea & soy in Asia miss the point, IMO. Dietary affluence in the West is the problem. It gives the body the go-ahead to invest in growth.
5' 9" tall (may have shrunk some, need to recheck), 4 lbs. 6 oz at birth. Not expected to live. Will consider Paleo Diet if I see any woolly mammoths wandering about.
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