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Precision oncology, THERANOSTICS & the Bad Berka Experience

pjoshea13 profile image
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New paper below [1].

For those who remember the days when there were few options, the list of potential therapies may seem bewildering.

"Precision oncology is being driven by rapid advances in novel diagnostics and therapeutic interventions, with treatments targeted to the needs of individual patients on the basis of genetic, biomarker, phenotypic, or psychosocial characteristics that distinguish a given patient from other patients with similar clinical presentations. Inherent in the theranostics paradigm is the assumption that diagnostic test results can precisely determine whether an individual is likely to benefit from a specific treatment. As part and integral in the current era of precision oncology, theranostics in the context of nuclear medicine aims to identify the appropriate molecular targets in neoplasms (diagnostic tool), so that the optimal ligands and radionuclides (therapeutic tool) with favorable labeling chemistry can be selected for personalized management of a specific disease, taking into consideration the specific patient, and subsequently monitor treatment response. Over the past two decades, the use of gallium-68 labeled peptides for somatostatin receptor (SSTR)-targeted PET/CT (or PET/MRI) imaging followed by lutetium-177 and yttrium-90 labeled SSTR-agonist for peptide receptor radionuclide therapy has demonstrated remarkable success in the management of neuroendocrine neoplasms, and paved the way to other indications of theranostics. Rapid advances are being made in the development of other peptide-based radiopharmaceuticals, small molecular-weight ligands and with newer radioisotopes with more favorable kinetics, potentially useful for theranostics strategies for the clinical application. The present review features the Bad Berka experience with first-in-human studies of new radiopharmaceuticals, for example, prostate-specific membrane antigen ligand, gastrin-releasing peptide receptor, neurotensin receptor 1 ligand, novel SSTR-targeting peptides and nonpeptide, and bone-seeking radiopharmaceuticals. Also new radioisotopes, for example, actinium (225Ac), copper (64Cu), scandium (44Sc), and terbium (152Tb/161Tb) will be discussed briefly demonstrating the development from basic science to precision oncology in the clinical setting."

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/314...

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pjoshea13
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cesanon profile image
cesanon

In this forum we have talked a lot about lutetium-177 and some about actinium (225Ac).

I don't recollect anything about yttrium-90, copper (64Cu), scandium (44Sc), and terbium (152Tb/161Tb)

Does anyone have any comments or opinions on these others?

I tried accessing the actual article, but couldn't get access.

Shanti1 profile image
Shanti1 in reply to cesanon

Hi Ceson, try using sci-hub.tw/ to access it. I was able to pull it up that way.

tango65 profile image
tango65

Thanks Patrick. This is the link to the full article:

sci-hub.tw/10.1053/j.semnuc...

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