Advanced Prostate Cancer.

[Carmichael55]

Hi,

Can anyone tell me if they are on the PATCH

trial using FemSevern patches for prostate

cancer and how they are getting on.

Thanks Alan L Turner.

[pjoshea13]

Our very own Richard Wassersug might be able to answer you. He is a long-time user of estradiol [E2] & was a co-author of one of the PATCH papers (2017):

"Quality-of-life outcomes from the Prostate Adenocarcinoma: TransCutaneous Hormones (PATCH) trial evaluating luteinising hormone-releasing hormone agonists versus transdermal oestradiol for androgen suppression in advanced prostate cancer."

ncbi.nlm.nih.gov/pubmed/?te...

-Patrick

[Wassersug]

Patrick has invited me to reply.

I tested out a couple of different estradiol patch products about 16 years ago, but not specifically FemSevern. I did not notice any real differences among the ones I tested. However I went over to using the gel product, estrogel. I have found it to be easier to manage and have been using it now for a decade and a half.

I don't know if that is much help, but if you want more information on using transdermal estradiol to control PSA, feel free to email me directly.

Richard W.

[Parscore in reply to Wassersug]

And do the patches help with PC. What impact does this have on PSA and the spread of the cancer? Sorry but have not heard of this before.

Thanks

[Carmichael55 in reply to Parscore]

Hi, am sorry for the late reply !

As you are aware my name is Alan, am

63 and live in the Uk. Today my PSA is 30, have not been told my gleeson score. Have just started an estrogen

patch trial 2 week's ago to reduce my

testosterone level. The patches are called FemSeven 100.4 patches are placed on my upper torso and changed every 4days. Am due to speak with my care nurse in 10 day's after my next blood test on 13th Aug.

Hope this info help's !

Will get back with more information, as soon as i have it.

Take care. Alan.

[Carmichael55 in reply to Wassersug]

Hi Richard, hope you are still ok.

Have only just started this patch trial 2weeks ago. PSA at June 12th was 30 so

my next check up is another 2weeks away. Think patch are to reduce my

testosterone ! in preparation for a course of chemotherapy.

Will let you know how or what my next

procedure will be, as soon as i hear.

Take care. Alan.

[Wassersug in reply to Carmichael55]

Alan,

Just a cautionary note....If you are candidate for chemotherapy, it might be because your cancer is now "castrate resistant". If you have been on an LHRH drugs like Lupron (=Lucrin) or Degarelix, and they no longer control your PSA, then high dose transdermal estradiol may also not be effective in providing PSA control. So far we do not have data to suggest that transdermal estradiol provides better PSA control than the standard ADT drugs. It may though be cheaper and provide better quality of life (noting that it does cause gynecomastia).

Richard W.

[Carmichael55 in reply to Carmichael55]

Hi Richard, good morning.

have not been on any other medication at this time !!! Just before my patch trial started, have had a nucleur bone scan and colonoscapy.

Both are clear !!! Am due a blood test on Tue Aug 13th to check PSA again.

So will let you know more next week.

Take care Alan...

[Break60]

I’m doing my own trial using patches by Sandoz. estradiol is generic and natural so the brand shouldn’t matter. See my profile. Great results.

[j-o-h-n]

Can you give us some information about yourself. AGE, LOCATION, PSA, GLEASON, TREATMENTS, TREATMENT CENTER, DOCTOR'S NAME(S)? All info is voluntary but it helps us help you and helps us too. If you respond please respond on a future date and NOT to me. Thank you.

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 08/01/2019 5:20 PM DST

[Break60 in reply to j-o-h-n]

John

Not sure if you were addressing your query to me. My profile tells most of the story. I’m now 75, live in S.C. , RP In ‘13 was at Johns Hopkins by Dr Schaeffer now head of Urology at Northwestern. SRT In ‘14 was by Dr Pablo in Savannah; IMRT to lymph nodes was in ‘15 by Dr Dattoli in Sarasota; SBRT to bone mets in ‘17 and ‘18 was by Dr Pablo in Savannah. Urologist is Dr Langley in Hilton Head .

Bobm

[j-o-h-n in reply to Break60]

Sorry Robert my bad, Right Church, Wrong Pew....

I was using a crooked cursor that day...and my hair got in front of my eyes...(and I'm bald)...

It was meant for Hoagy.....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 08/06/2019 8:29 PM DST

[Break60 in reply to j-o-h-n]

🤬

[j-o-h-n in reply to Break60]

✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌✌

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 08/07/2019 6:16 PM DST

[Break60 in reply to j-o-h-n]

🤭🤐