Looking for data-

[DSEE]

Looking for data-currently on taxotere and just finished 3rd infusion-

Sharp increase over 200 points in Alk pho’s and AST, ALT.

Yes I have bone and liver Mets- but this is second rechallenge with Taxotere after first in 2016- numerous treatments- Xofigo Xtandi Zytiga -

You would think if taxotere is effecting cancer growth those levels would go down and not sharply increase.

No pain- just chemo side effects.

If anyone has data on sharp increase in these three areas during taxotere please advise-

They are Alkaline phosphate - AST

and ALT-

Have all greatly increased-

Many thanks-

Will ask MO on visit 8-05 also.

[Hidden]

What is your PSA?

[DSEE in reply to Hidden]

Was up to 30 in June.

[Hidden in reply to DSEE]

Have you talked about getting a biospy? If you aren't responding to treatment, I would be trying to figure out why. You could do molecular testing for somatic gene mutations and also see if there is Neuroendocrine Differentiation. This might help you direct your treatment to something that would give you a better response. Something to discuss with your doctor.

[DSEE]

Had gene mutation testing and there was no mention of neuroendocrine-

Mutations did not open up to treatments- in other words did not have the right mutation. BRCA- etc.

[Hidden in reply to DSEE]

Did they take a tissue sample or was it a "liquid biospy"? You can tell gene mutations with a circulating tumor cells (blood test), but to see neuroendocrine cells you need a tissue sample.

[DSEE in reply to Hidden]

Tissue sample was taken from liver tumors on 4-08 this year.

That was where MO got results stating no gene mutation.

[Hidden in reply to DSEE]

There is second-line chemotherapy Jevtana you could try. There is also a trial for LU-177 (VISION).

[NPfisherman in reply to DSEE]

What mutation?? There are some immunotherapy drugs in trials in other cancers and proof that there is potential to treat based on mutation and not cancer type...

Don Pescado

[tango65]

Did you have provenge? I believe Provenge may offer a survival advantage. You may qualify for the lu 177 PSMA trials.

clinicaltrials.gov/ct2/resu...

Docetaxel could cause alkaline phophatase flares but it is less common than with enza or abi.

futuremedicine.com/doi/full...

[larry_dammit]

Mine went down then up then down. Bone Mets dying off was what the doctor said 🙏🙏🙏

[DSEE in reply to larry_dammit]

That is what I wanted to know.

To hear that such a sharp increase may mean chemo is working-

Thanks-

[Hidden in reply to DSEE]

You will only really know where you are several weeks after the last chemo. The PSA typically goes down after the chemo for about 3 to 4 weeks, and then starts rapidly climbing again as the immune system starts to kill cancer cells once again (chemo trashes the immune system which is why you get false low PSA readings for a while). It is where that climb levels off - if it keeps going, you are one of the unlucky ones where chemo did more harm than good. If it stays low, that would be a success. That said, I see the odd person reports raised PSA soon after chemo, and that then declines and stays low. Perhaps they have a cast-iron immune system! Everyone is different!

[CantChoose in reply to Hidden]

My husband's PSA rose after the second chemo. I looked it up and it seems only about 20% of people have this happen. There was no tie to outcomes (it wasn't better to have it go up).

If it's still rising after four, they'll move on to something else. Four seems to be the magic number of required rounds to know if the PSA is a blip or a failure.

[Rexwaterbury]

You could add carboplatin. I have had 3 cycles of taxotere and carboplatin with a good response, PSA from 18 to 10, shrinking lymph node Mets.

[monte1111]

I had about 50 point alk phos. flare after first chemo. Then slow decline to normal levels over many months. About 167 before and 220 after.

[Ldb01]

My hubby had these with Taxotere and even more with JEVTANA