Starving stem cells: McLelland survived stage 4 cervical cancer (since 1999) AND later leukemia (caused by therapy to 1st cancer) putting together a cocktail of off-label drugs and nutraceutical supplements in an attempt to block the pathways that cancer stem cells use for fuel. This metabolic approach effectively “starved” her cancer of its fuel (glucose, glutamine, and fat) and she healed herself.
The idea is to block all the pathways at the same time. Many drugs already known like Metformin, Statin, Berberine, as well as antiworm drugs, low dose antibiotic, and other supplements.
Prostate cancer should be more on the fat and glutamine pathway, but for advanced prostate cancer also glucose pathway should be blocked.
Interesting book "How to starve cancer" and also FB group.
Here the abbreviations:
Glut 1= Glucose Transporter 1, Insulin, PP Pathway= Pentose Phosphate Pathway, OXPHOS= Oxidative Phosphorylation, Aerobic Glycolysis
Glutamine/Amino Acid Pathways
IGF-1= Insulin like growth factor-1, Gln OXPHOS= Glutamine oxidative phosphorylation, mTOR= mammalian target of rapamycin, Macropinocyctosis (Autophagy) Nucleoside Salvage (Autophagy), Glutaminolysis, Acetate Pathway
Fatty Acid Pathways
SREBP-1= Sterol Regulating End Binding Protein-1, SREBP-2= Sterol Regulating End Binding Protein-2, ACLY= ATP Citrate Lyase, F.A.S.= Fatty Acid Synthesis, F.A.O= Fatty Acid Oxidation, Mevalonate Pathway
TREATMENTS (written in colour)
MET= Metformin, TAM= Tamoxifen, BERB= Berberine, DOXY= Doxycycline, NICL=Niclosamide, CHLQ= Chloroquine, DPM= Dipyridamole, EGCG= Epigallocatechin Gallate, URS= Ursolic Acid, CUR= Curcumin, RES= Resveratrol, L-ASP= Asparaginase, BPTES= bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulphide, MIL=Mildronate, IVC= intravenous vitamin C, 2DG= 2-Deoxyglucose, DCA= Dichloroacetate, 3BP=3-Bromopyruvate, Low GI= Low Glycaemic Diet, CHR= chromium picolinate, QUERC= Quercetin