Hope for PTEN reactivation?

[podsart]

Wondering what you guys think of this

science.sciencemag.org/cont...

[cesanon]

Interesting, though it seems like many years out before it results in an accessable treatment.

[podsart in reply to cesanon]

What about use of reputable supplement that provides a rather natural strong highly absorbable format , of , say broccoli sprouts/seed — not sure if broccomax fits this :

“ BroccoMax® broccoli seed extract is manufactured using a patented process that preserves myrosinase, the enzyme in broccoli that metabolizes SGS (Sulforaphane Glucosinolate, a.k.a. glucoraphanin) in the small intestine into sulforaphane “

[cesanon in reply to podsart]

Personally I don't believe there is such a thing as a "reputable supplement"

You need to start with a reputable supplier. Also somewhat rare.

Personally the only supplier I sort of trust is Lef.org. And if they don't elect to carry any particular supplement, it already means it is suspect from wherever I can buy it.

Don't forget the following is of no consequence unless you have someone who is knowledgeable enough to vet it for you. I don't know what they are saying, let alone am I able to verify what they are saying and what they are not saying. And most likely it is being sourced out of China. I never knowingly buy food, medications or supplements with a supply chain that comes within 500 miles of China.

“ BroccoMax® broccoli seed extract is manufactured using a patented process that preserves myrosinase, the enzyme in broccoli that metabolizes SGS (Sulforaphane Glucosinolate, a.k.a. glucoraphanin) in the small intestine into sulforaphane “

[podsart in reply to cesanon]

Thanks

[Hidden in reply to cesanon]

Personally I believe that their are many reputable supplements . I follow my naturalpathic onocologist . Dr. Michael Uzick .

[cesanon in reply to Hidden]

There is a wide range of of diverse opinion on this subject.

[Hidden in reply to cesanon]

Just like everything else in the world . Each to their own amigo. 🌵

[Hidden in reply to podsart]

Great stuff. Hell yah! Choppin broccoli!

[podsart]

Interesting, looking forward to what you report-any idea when you will post this?

Thanks

[Hidden]

It ain’t easy wrestling Gators for a living . Keep truckin Nal! 🐊

[kaptank]

I3C and DIM (and broccoli sprouts!) are looking like serious supplements for our purposes. This is a useful summary of what is known about I3C and its metabolite, DIM from the Pauling Institute.

lpi.oregonstate.edu/mic/die...

[farmanerd in reply to kaptank]

Make sure that you read or page through to the end of the linked page and the second paragraph below:

"Safety

Adverse effects

Slight increases in the serum concentrations of the liver enzyme, alanine aminotransferase (ALT) were observed in two women who took unspecified doses of I3C supplements for four weeks (39). One person reported a skin rash while taking 375 mg/day of I3C (35). High doses of I3C (800 mg/day) have been associated with symptoms of disequilibrium and tremor, which resolved when the dose was decreased (85). In a phase I study in women at high risk for breast cancer, 5 out of 20 participants had gastrointestinal symptoms with single doses ≥600 mg, although others had no adverse effects with single doses up to 1,200 mg (6). No adverse effects were reported with daily consumption of 400 mg of I3C for four weeks (6).

In some animal models, I3C supplementation was found to enhance carcinogen-induced cancer development when given chronically after the carcinogen (96-99). When administered before or at the same time as the carcinogen, oral I3C inhibited tumorigenesis in animal models of cancers of the mammary gland (100, 101), uterus (102), stomach (103), colon (104, 105), lung (106), and liver (107, 108). Although the long-term effects of I3C supplementation on cancer risk in humans are not known, the contradictory results of animal studies have led several experts to caution against the widespread use of I3C and DIM supplements in humans until their potential risks and benefits are better understood (99, 109, 110)."

Our bodies are miraculously complex systems.

[kaptank in reply to farmanerd]

Well spotted! Also the last sentence of the Cancer Risks section:

"At present, the effects of I3C or DIM supplementation on cancer risk in humans are not known."

Reading some of those more technical paragraphs is above my intellect and pay grade but by and large I thought it a useful and fair summary. The phenomenon of bipolarity is reasonably common and something to bear in mind with a number of supplements. (bipolarity being where under some conditions an agent can suppress cancer but in other conditions can encourage its growth) These are matters to be addressed in the dosing strategy and timing and sequencing. In my own treatment I am comfortable at the moment with a modest dose of DIM supplemented with a daily handful of fresh broccoli sprouts, well chewed.

[podsart]

Thanks, excellent

Is there a way to determine how effective broccomax is in generating I3C , and perhaps DIM?