PSA Undetectable for a year, but...

[gvweller]

About a year ago I wrote here that three treatments with Keytruda had reduced my PSA to "undetectable (<.10)". Later I had a terrible sinus infection, big headaches, and my to be cautious, my oncologist stopped Keytruda (the docs thought maybe the headache was a reaction to Keytruda). Well, no matter. Eight days of IV antibiotics took care of the sinus problem. A year later, PSA is still undetectable. (WooHoo!!)

There's just one problem. My testosterone is also undetectable. Which means not only are the testes doing nothing, neither are the adrenals. A battery of tests revealed no other hormonal issues. So, do any of you folks know anyone who was on ADT for TEN YEARS and recovered normal testosterone? (Yeah, I know, most guys on ADT that long have passed.)

Best regards, and keep up the fight!

[Hidden]

It’s great news really. I’ve been undetectable with adt for 3yrs but I did orchiectomy 9-16 also. My “T has been steady at 3 .. if I ever feel like trying “T” I’ll need to inject it. Testosterone for us is dammed if you do ,dammed if you don’t.. My layman’s opinion only ..

[Tall_Allen]

Congratulations! Sometimes clomid or hCG can jumpstart natural testosterone production.

[Magnus1964]

That is fantastic. What treatments did you have prior to Keytruda?

[gvweller in reply to Magnus1964]

Wow. Radical prostatectomy, salvage radiation to the pelvic bed, ADT, Casodex, Xgeva, radiation to left shoulder, Zytiga+steroids, Xtandi, total reverse shoulder replacement. You can tell that the shoulder (and humerus) were a big problem. About the time we were considering Provenge, there was a substantial spontaneous regression, so Provenge was never used, then Zytiga became available. All the above was over a period of ten years. Often the doubling time was down around 30 days. When Xtandi failed, they sent me to Ann Arbor for a clinical trial. Genetic testing there showed that Keytruda would probably work. It did. I'm a lucky guy.

[j-o-h-n in reply to gvweller]

Congrats! Keytruda is working on my melanoma lung cancer also. ($30K per injection)

Good Luck, Good health and Good Humor.

j-o-h-n Monday 03/11/2019 2:16 PM EDT

[Hidden]

After 6 years of Lupron/Eligard and a 6 month chemo trial with two different infusion drugs plus 5 different orals, my T never came back. I stopped ADT in February 2010...... well my PSA is still undetectable and the Mets are long gone. A year later in 2011, my Medical Oncologist put me on 4 mg of Androgel twice a week in an effort to jumpstart T. Never happened. I remain in low dose testosterone gel..... T ranges from 350 to 750 depending when I apply the gel and have my quarterly blood draw.

Count your self lucky that T is less than 5 and PSA is less than <0.1......... Good job.

Gourd Dancer

[gvweller in reply to Hidden]

Interesting! Thanks.