Into TRITON II - and awaaay we go!

[Stegosaurus37]

OK, 2 weeks into the trial. 75% of participants get nausea, vomiting. I never do anything the way others do so none of that for me. Instead constipation with stool as hard as concrete. Miralax, senokot magnesium citrate, Gavrilate. Nothing. So into the ER where the X-ray shows "you're full of it". Well my wife has been telling me that for lo these many moons but I don't think she meant it literally. A nurse made the insightful comment that all the stuff I'd been taking was top down and what I needed was bottom up. Too true; a soapsuds enema and it worked. I don't envy the guy who had to clean up the room. Everything tickety-boo since then. As far as constipation goes.

But the severe constipation made it also impossible for me to urinate. So the ER put a Foley catheter in me and took out 2 liters of urine. The catheter was needed. On a temporary basis but then I didn't need it anymore and wanted it out. I won't bore you with the details but the level of bureaucracy and red tape was truly unbelievable. Fortunately I had to go to the VA for a check two days later and they didn't bother with bureaucracy. Catheter out (yes, I did scream but it wasn't nearly as bad as I thought it would be) and I've been peeing and defecating normally since then.

However I do NOT want a repeat and have been taking senokot and prune juice ever since. And my primary care (who is really great) has given me a scenario for if things go wrong in the future. So I feel good.

Bottom line: if you feel something is going wrong with your side effects, do NOT wait - get it taken care of.

I said I never do anything anybody else does and that's true with side effects. The constipation was 35% of participants, but I had another. My energy level has greatly increased. We normally think of side effects s being always negative but here is a positive one. Hey, I may be able to get back out to the rifle range pretty soon. I feel that I could do it now; just need some warmer weather.

[NPfisherman]

Great news....glad the trial is working out well for you...please post how your PSA results are coming in on the drug, and... Just keep going....literally...

All the best,

Fish

[Drcrunch]

What drug are they testing

[Drcrunch in reply to Drcrunch]

Is it rucaparib

[Stegosaurus37 in reply to Drcrunch]

It is rucapafib

[NPfisherman]

Thank you for participating in the trial. Your courage and desire to advance knowledge about our disease is applauded here.

Best of luck,

Fish

[j-o-h-n]

Should I repeat my story about the meanest animal in the world? Never mind it's too long and not that funny.

You're fortunate that they gave you the soap suds enema and not "the plumber's helper trick"...

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 02/24/2019 1:56 PM EST

[Shooter1]

Sounds like you are braving the path for us..than you for your service. I'll hit the rifle range on Weds. for first time in over two years.

[Stegosaurus37 in reply to Shooter1]

Great for you! The clinical trial is sort of a last gasp. I'm castrate-resistant and Xtandi-resistant so there's nothing else in the line-up. Chemo works but only as long as I'm on it. Doesn't get me anything more. I've got one tough mother cancer. Doesn't take nothing from nobody.

One weird thing. My PSA had had a six weeks doubling time. When I went off Xtandi - essentially just on lupron, the PSA rise slowed very dramatically. Will be interested to see what it does now. I never do anything everybody else does.

Keep on keeping on. If you can't find a silver lining, look for a gold one.