I noticed some of you take high doses of Vit D but blood levels don't go up that much.
Could it be related to intake form? When taking in liquid form Vit D levels go up, but doesn't seem to work in pill form, in my experience.
What are your blood levels with high intake?
Any worries with hypercalcemia?
Life Extension matched users of their old cholecalciferol product to those who had also purchased their LabCorp vitamin D tests. Many who were using up to 5,000 IU had lowish numbers.
They responded by switching to a softgel with an oil base & upping the max dose to 7,000 IUs.
Vitamin D should be taken with a meal that contains fat.
I don't believe that hypercalcemia / hypervitaminosis D is an issue if one is taking vitamin K2 too.
I would avoid cholecalciferol products that do not contain oil.
-Patrick
Are you sure you are taking "D3" not just plain D. D3 is in absorbable form
It's because our bodies have complex mechanisms for controlling the amount of all steroids, including Vitamin D,that get released into the plasma. You can overwhelm your body's defenses, but your body will fight back. It will also pull calcium out of bone if plasma levels are too high.
You wrote:
"It's because our bodies have complex mechanisms for controlling the amount of all steroids, including Vitamin D,that get released into the plasma."
but there is a more mundate expanation. Vitamin D is fat-soluble and not readily taken up in the absence of fat.
-Patrick
Very few of us consume diets totally devoid of fats. If we want to avoid fat with a pill (as with abiraterone) we have to take special measures - like no food 2 hours before or one hour after. Assuming there is at least some fat to carry Vitamin D through the bowel walls, we have strict homeostatic biochemistry that prevents excess free Vitamin D in the plasma. Excess beyond that homeostatic set point is stored in fat and the liver. Homeostasis is protective because excess plasma levels can pull calcium out of bones.
Hey Myriammole,
I use the expertise of a very forward thinking Doc. When I first went to him we had the discussion and tests to evaluate my health and cancer. Part was a blood test that tested for among many other things, my vitamin D level. On the follow up visit to discuss the results I was instructed to bring in all the supplements I take and so on. He wanted to examine the supps to see what, how often and how much I took. He went over my results while asking questions and looking at the supps I had arranged out on a table. When he got to vitamin D he seemed to expect my levels to be low as with most of his patients I assume from the look on his face. He then picked up my DD supp and did a "hmmm!" sort of thing while nodding his head in a positive way. My results were very good for D.
I take the Vitamin Shoppe's own brand of liquid D. I do a couple drops more than the directions specify, however, body weight isn't factored into the dosage. Just me doing my tweak.
I had heard, and commented to this effect, that vit D3 could be implicated in being more prone to atrial fibrillation episodes. The following research indicates that this claim is false.
My Vit D level was 28 when first measured three years ago. I began with very high doses (10,000u) before my Pca Dx. Reduced it (5,000u) after endo consult and my Dx of Pca. (level in 30s & 40s) I am Low T as well. After beginning T gel my level improved to low 50s for first time, which was 16 months ago. My last level in Dec' 18 was 75!! I will be reducing my dose. Documented osteopenia on BMD scan, first done 3 yrs ago. The T gel is on hold as T report at 970 & my PSA also came back at 0.015 (had been <0.006 for two yrs.) See my info on earlier post. PSA <0.006 one month after holding T gel and then 0.014 10 days after starting again at 1/2 prior dose. T had fallen to 298 and rose to 461 with resumption of the Tgel which is currently on hold again. Labs will be drawn again in two weeks.
vitamin D3 or Vitamin D 
Vitamin D / The Optimal Dose, Dr. Judson Somerville
Vitamin D levels
