CAR T-Cell Therapy. Anyone on or have... - Advanced Prostate...

Advanced Prostate Cancer

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CAR T-Cell Therapy. Anyone on or have heard about it? Might be promising.

BarronS profile image
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Medicare will start paying for a new cancer therapy called "CAR T-Cell Therapy" axios.com/medicare-will-pay...

I read that it was promising in animal models when it came to prostate cancer and there are two phase I trials being conducted right now on mCRPC. Was just wondering if anyone is on this or has heard of someone being on it.

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BarronS profile image
BarronS
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Tall_Allen profile image
Tall_Allen

CMS is only proposing coverage for:"Treatment is an FDA-approved biological, providing targeted therapy for a known antigen expressed in the patient’s cancer according to an FDA indication in a hospital. " So far, the FDA has only approved it for children and young adults with a form of acute lymphoblastic leukemia (ALL).

For prostate cancer, all I've seen so far are this early (Phase 1) trial at UOP with results expected next year:

clinicaltrials.gov/ct2/show...

This small phase 1 trial at MSK:

clinicaltrials.gov/ct2/show...

and this Phase 1/2 study at Moffitt, Columbia and Baylor Sammons:

clinicaltrials.gov/ct2/show...

I know that City of Hope is also working on a clinical trial. There may be others. We seem to be a long way off from the phase 3 trials that might get FDA approval.

tango65 profile image
tango65

It is a promising therapy. Some good results in acute leukemia.

ncbi.nlm.nih.gov/pubmed/296...

This is a list of active trials for prostate cancer:

clinicaltrials.gov/ct2/resu...

FCoffey profile image
FCoffey

Prostate cancer is a "cold" tumor, meaning that if you examine the tumor there are very few T cells. The mechanisms whereby the cancer excludes T cells, or kills them, or turns other immune cells from attackers to promoters of the cancer are not fully understood. It's complex and there is a lot of research underway.

Leukemia and melanoma are different; T cells are able to get to the cancer. So CAR-T therapy seems to work better for those types of cancer.

A lot of researchers and clinicians believe that immune system treatments are the most promising avenues for improving prostate cancer outcomes. Maybe Axios will solve the puzzle, maybe someone else will. Right now, we just don't know.

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