I read that it was promising in animal models when it came to prostate cancer and there are two phase I trials being conducted right now on mCRPC. Was just wondering if anyone is on this or has heard of someone being on it.
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BarronS
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CMS is only proposing coverage for:"Treatment is an FDA-approved biological, providing targeted therapy for a known antigen expressed in the patient’s cancer according to an FDA indication in a hospital. " So far, the FDA has only approved it for children and young adults with a form of acute lymphoblastic leukemia (ALL).
For prostate cancer, all I've seen so far are this early (Phase 1) trial at UOP with results expected next year:
I know that City of Hope is also working on a clinical trial. There may be others. We seem to be a long way off from the phase 3 trials that might get FDA approval.
Prostate cancer is a "cold" tumor, meaning that if you examine the tumor there are very few T cells. The mechanisms whereby the cancer excludes T cells, or kills them, or turns other immune cells from attackers to promoters of the cancer are not fully understood. It's complex and there is a lot of research underway.
Leukemia and melanoma are different; T cells are able to get to the cancer. So CAR-T therapy seems to work better for those types of cancer.
A lot of researchers and clinicians believe that immune system treatments are the most promising avenues for improving prostate cancer outcomes. Maybe Axios will solve the puzzle, maybe someone else will. Right now, we just don't know.
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